Results 181 to 190 of about 5,041,695 (380)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Super-resolution imaging of T lymphocyte activation reveals chromatin decondensation and disrupted nuclear envelope

Communications Biology
T lymphocyte activation plays a pivotal role in adaptive immune response and alters the spatial organization of nuclear architecture that subsequently impacts transcription activities.
Jianquan Xu, Xuejiao Sun, Zhangguo Chen, Hongqiang Ma, Yang Liu   +4 more
doaj   +1 more source

Flow cytometric analysis of nuclear DNA content in oral lesions.

, 1992
Tatsuo Tsuji, Kohsuke Sasaki, Yuka Kimura, Tomoyuki Murakami, Masamichi IDA, Akihiro Kanekawa, Tsukasa KUZUYAMA, Fumihiko Shinozaki   +7 more
openalex   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Horizontal transfer of nuclear DNA in transmissible cancer. [PDF]

Proc Natl Acad Sci U S A
Gori K, Baez-Ortega A, Strakova A, Stammnitz MR, Wang J, Chan J, Hughes K, Belkhir S, Hammel M, Moralli D, Bancroft J, Drydale E, Allum KM, Brignone MV, Corrigan AM, de Castro KF, Donelan EM, Faramade IA, Hayes A, Ignatenko N, Karmacharya R, Koenig D, Lanza-Perea M, Lopez Quintana AM, Meyer M, Neunzig W, Pedraza-Ordoñez F, Phuentshok Y, Phuntsho K, Ramirez-Ante JC, Reece JF, Schmeling SK, Singh S, Tapia Martinez LJ, Taulescu M, Thapa S, Thapa S, van der Wel MG, Wehrle-Martinez AS, Stratton MR, Murchison EP.   +40 more
europepmc   +2 more sources

Characterization of nuclear DNA diversity in an individual Leymus chinensis. [PDF]

Front Plant Sci, 2023
Yu H, Ma L, Zhao Y, Naren G, Wu H, Sun Y, Wu L, Zhang L.   +7 more
europepmc   +1 more source

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

Nature, 2021
M. Tigano, Danielle C. Vargas, Samuel Tremblay-Belzile, Yinxu Fu, Agnel Sfeir   +4 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Distribution of Hepatitis B Virus Nuclear DNA

Journal of Virology, 2017
Mingming Li, Ji A. Sohn, C. Seeger
semanticscholar   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source