Results 21 to 30 of about 28,546 (217)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Analysis of particles containing alpha emitters in stagnant water in Fukushima Daiichi Nuclear Power Station’s Unit 3 reactor building

Scientific Reports
Particles containing alpha (α) nuclides were identified from sediment in stagnant water in the Unit 3 reactor building of the Fukushima Daiichi Nuclear Power Station (FDiNPS).
Takumi Yomogida, Kazuki Ouchi, Shiori Morii, Toshitaka Oka, Yoshihiro Kitatsuji, Yoshikazu Koma, Katsuhiro Konno   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Implementation of functional expansion tally method and order selection strategy in Monte Carlo code RMC

Nuclear Engineering and Technology, 2021
The spatial distribution of neutron flux or reaction rate was calculated by cell or mesh tally in traditional Monte Carlo simulation. However, either cell or mesh tally leads to the increase of memory consumption and simulation time.
Zhenyu Wang, Shichang Liu, Ding She, Yang Su, Yixue Chen   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A new theoretical performance analysis method considering longitudinal and transverse end effects for flat linear induction magnetohydrodynamic pumps

Frontiers in Nuclear Engineering
The flat linear induction pumps (FLIPs) are a class of driving devices that converts electromagnetic energy into mechanical energy of pumped liquid metal, which are widely used in the field of energy power and chemical industries.
Ming Ding, Chunwei Yang, Yifan Bai, Keming Bi, Xin Yan   +4 more
doaj   +1 more source

IAEA coordinated research project on nuclear data for charged-particle monitor reactions and medical isotope production

EPJ Web of Conferences, 2017
An IAEA coordinated research project was launched in December 2012 to establish and improve the nuclear data required to characterise charged-particle monitor reactions and extend data for medical radionuclide production.
Capote Roberto, Nichols Alan L., Nortier Francois Meiring, Carlson Brett V., Engle Jonathan W., Hermanne Alex, Hussain Mazhar, Ignatyuk Anatoly V., Kellett Mark A., Kibédi Tibor, Kim Guinyun, Kondev Filip G., Lebeda Ondrej, Luca Aurelian, Naik Haladhara, Nagai Yasuki, Spahn Ingo, Suryanarayana Saraswatula V., Tárkányi Ferenc T., Verpelli Marco   +19 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source