Results 31 to 40 of about 28,546 (217)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development and Verification of CUPID-MSR Using the de Vahl Davis Natural-Convection Benchmark

Energies
This study provides the first systematic verification of the CUPID-MSR thermal–hydraulic code for molten-salt reactor applications, incorporating temperature-dependent thermophysical properties of two chloride-based molten salts, KCl–UCl3 and NaCl–MgCl2 ...
Rafał Stoga, Jae Ryong Lee, Han Young Yoon   +2 more
doaj   +1 more source

The CIELO collaboration: Progress in international evaluations of neutron reactions on Oxygen, Iron, Uranium and Plutonium

EPJ Web of Conferences, 2017
The CIELO collaboration has studied neutron cross sections on nuclides that significantly impact criticality in nuclear technologies – 16O, 56Fe, 235,8U and 239Pu – with the aim of improving the accuracy of the data and resolving previous discrepancies ...
Chadwick M.B., Capote R., Trkov A., Kahler A.C., Herman M.W., Brown D.A., Hale G.M., Pigni M., Dunn M., Leal L., Plompen A., Schillebeeck P., Hambsch F.-J., Kawano T., Talou P., Jandel M., Mosby S., Lestone J., Neudecker D., Rising M., Paris M., Nobre G.P.A., Arcilla R., Kopecky S., Giorginis G., Cabellos O., Hill I., Dupont E., Danon Y., Jing Q., Zhigang G., Tingjin L., Hanlin L., Xichao R., Haicheng W., Sin M., Bauge E., Romain P., Morillon B., Noguere G., Jacqmin R., Bouland O., De Saint Jean C., Pronyaev V.G., Ignatyuk A., Yokoyama K., Ishikawa M., Fukahori T., Iwamoto N., Iwamoto O., Kuneada S., Lubitz C.R., Palmiotti G., Salvatores M., Kodeli I., Kiedrowski B., Roubtsov D., Thompson I., Quaglioni S., Kim H.I., Lee Y.O., Koning A.J., Carlson A., Fischer U., Sirakov I.   +64 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Research on Lightweight Technology of Hydraulic Components for Integrated Fast Reactor Main Pump

Yuanzineng kexue jishu
To meet the requirements of our country’s nuclear energy development and defense technology industry development, and to achieve national carbon neutrality and energy security needs, it is necessary to comprehensively break through and master the key ...
PU Enshan1, ZHAI Xiao1, GU Jipin1, LIU Simin1, ZHANG Xu2
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Performance Test of High-temperature Immersion Pump for In-reactor Purification of Integrated Fast Reactor

Yuanzineng kexue jishu
In the integrated fast reactor project of the China Institute of Atomic Energy, in order to keep the primary circuit sodium within the reactor and prevent radioactive sodium leakage, an in-reactor cold trap is used to purify the impurities in the sodium,
LI Xu1, GENG Xiao1, YAO Zewen1, , YU Chunli1, WU Peng2, YU Genfang2
doaj   +1 more source

Optimization Research of Neutron Flux Density Monitoring Method during Refueling for Tianwan NPP

Yuanzineng kexue jishu, 2023
The ex-core nuclear instrument equipment consists of the source range detector, the start-up and work range detector and the refueling monitoring range detector in Tianwan nuclear power plant (NPP). The neutron flux density of the reactor is monitored by
LYU Niu;LI Dongpeng;XIA Zhaodong;WANG Yang
doaj