Results 51 to 60 of about 626,436 (290)

Investigation of a dynamic measurement methodology for fast detection of gross defects in regularly distributed nuclear material samples

open access: yesHeliyon, 2019
Non-Destructive Assay (NDA) techniques are widely used to verify Nuclear Materials (NM). Most of these techniques are static ones for which, the measuring device and the assayed samples are located at fixed positions during measurements.
W. El-Gammal, M. Darweesh, S. Shawky
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Nuclear Security Training: A New Approach for Educating Nuclear Technology in Indonesia

open access: yesE3S Web of Conferences, 2018
Indonesia has planned to erect Nuclear Power Plant for along time, but the government always postponed the plan due to the presence of anti-nuclear group that decreases the public acceptance.
Ferdiansjah   +4 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Synchronous collaborative application of nuclear power engineering design platform

open access: yesDianxin kexue, 2017
At present,the nuclear power business shows the development trend of multi-route,multi-base develop-ment trend.Coupled with the huge workload of nuclear power engineering design and the fine division of labor cha-racteristics,the relevant professional in
Zhihua ZENG, Delong YI, Yan LI
doaj   +2 more sources

Developing and Promoting a Nuclear Security Curriculum at Amity University, India: Beginnings, Successes and Challenges

open access: yesInternational Journal of Nuclear Security, 2016
Amity University is one of India’s leading research- and innovation-driven private universities. The Amity Institute of Nuclear Science and Technology (AINST), established in 2009, contribute to Amity’s mission to promote national development through ...
Kawalpreet Kalra   +2 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Design and Economic Characteristics of Severe Accident Mitigation Strategies for Nuclear Power Plants

open access: yes南方能源建设
[Objective] During the development of China nuclear power industry, a variety of foreign developed reactors have been introduced,therefore the severe accident mitigation strategies in China is multifarious.
Yuqi XIA, Guangyu ZHU, Kunpeng WANG
doaj   +1 more source

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