Results 311 to 320 of about 1,892,385 (358)

Nuclear organisation and gene expression

Current Opinion in Cell Biology, 2002
The development of increasingly sophisticated tools to track chromosomes and proteins in living cells offers the possibility of visualising gene regulation in the nucleus with minimal distortion. This, in conjunction with powerful genetic approaches available in yeast, is beginning to allow functional definition of nuclear "compartments".
Jonathan, Baxter, Matthias, Merkenschlager, Amanda G, Fisher   +2 more
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Nuclear genes in mitochondrial disorders

Current Opinion in Genetics & Development, 2003
Nuclear genes encode hundreds of proteins involved in mitochondrial biogenesis and oxidative phosphorylation (OXPHOS). Nevertheless, the identification of nuclear genes responsible for OXPHOS-related disorders has proceeded at a much slower pace, compared with the discovery and characterization of mtDNA mutations.
Zeviani M., Spinazzola A., Carelli V.
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Nuclear compartments and gene regulation

Current Opinion in Genetics & Development, 1999
Improvements in fluorescence microscopy have allowed us to explore the three-dimensional organization of the nucleus in ways that were impossible ten years ago, revealing subdomains or compartments within the nucleus defined by their enrichments of subsets of factors.
M, Cockell, S M, Gasser
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Nuclear compartmentalization and gene activity

Nature Reviews Molecular Cell Biology, 2000
The regulated expression of genes during development and differentiation is influenced by the availability of regulatory proteins and accessibility of the DNA to the transcriptional apparatus. There is growing evidence that the transcriptional activity of genes is influenced by nuclear organization, which itself changes during differentiation.
C, Francastel, D, Schübeler, D I, Martin, M, Groudine   +3 more
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Nuclear Organization and Gene Expression

Experimental Cell Research, 1996
In actively transcribing cells, factors involved in pre-mRNA splicing localize in a speckled pattern at the fluorescence microscopic level. The speckled pattern corresponds to interchromatin granule clusters and perichromatin fibrils at the electron microscopic level. Based upon [3H]uridine incorporation studies transcription is thought to occur at the
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Gene-gene coordination by the nuclear envelope

Medical Hypotheses, 1995
The paper studies how certain topologic features of the nuclear envelope may reorganize entrained transcription via spatial rearrangements of genes carried by distinct chromatids.
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Tetrapyrrole regulation of nuclear gene expression

Photosynthesis Research, 2002
Tetrapyrroles are the structural backbone of chlorophyll and heme, and are essential for primary photochemistry, light harvesting, and electron transport. The biochemistry of their synthesis has been studied extensively, and it has been suggested that some of the tetrapyrrole biochemical intermediates can affect nuclear gene expression. In this review,
Judy A, Brusslan, Michael P, Peterson
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THE NUCLEAR HORMONE RECEPTOR GENE SUPERFAMILY

Annual Review of Medicine, 1995
▪ Abstract  The nuclear hormone receptor gene superfamily encodes structurally related proteins that regulate transcription of target genes. These macromolecules include receptors for steroid and thyroid hormones, vitamins, and other proteins for which no ligands have been found. These receptors have modular domains. The DNA-binding domain directs the
R C, Ribeiro, P J, Kushner, J D, Baxter
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Artificial modification of nuclear gene activity

International Journal of Biochemistry, 1981
Abstract 1. 1. Various experimental systems in which nuclear gene activity may be artificially modified are discussed and compared. 2. 2. The experimental systems discussed include the construction of hybrid cells by heterokaryon formation, or nuclear transplantation techniques; the injection of cell extracts into cells; and various cell-free
S P, Gregory, N, Maclean, M J, Pocklington   +2 more
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Searching for nuclear-mitochondrial genes

Trends in Genetics, 2003
Recently, a novel strategy has been developed to identify yeast genes that are important for mitochondrial respiratory chain function. This approach found a large number of genes that were not previously thought to be involved, providing new candidate disease genes for mitochondrial disorders.
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