Results 321 to 330 of about 1,892,385 (358)
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POLRMT does not transcribe nuclear genes
Nature, 2014Arising from J. E. Kravchenko, I. B. Rogozin, E. V. Koonin & P. M. Chumakov , 735–739 (2005); doi:10.1038/nature0384810.1038/nature03848 Mitochondria are involved in a variety of metabolic processes and one of their main functions is to perform oxidative phosphorylation1,2, which requires a ...
Inge Kühl +8 more
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Nuclear proteins as gene‐transfer vectors
Biotechnology and Applied Biochemistry, 2005An interest in nuclear proteins as possible gene vectors arose as early as 1988. Nuclear proteins possess important features, such as DNA condensing capacity and the presence of NLSs (nuclear localization signals), which are thought to be perfect tools to combine cellular and nuclear uptake of DNA.
Annekathrin, Haberland +1 more
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Nuclear gene defects in mitochondrial disorders
Neurological Sciences, 1999An increasing number of nuclear genes have been associated with abnormalities of oxidative phosphorylation and mitochondrial disorders. The protein products of these genes can be grouped into three categories: structural components of the respiratory chain, factors influencing the structural integrity or the copy number of mitochondrial DNA, and ...
Zeviani M. +3 more
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Gene Silencing by Nuclear Orphan Receptors
2004Nuclear orphan receptors represent a large and diverse subgroup in the nuclear receptor superfamily. Although putative ligands for these orphan members remain to be identified, some of these receptors possess intrinsic activating, inhibitory, or dual regulatory functions in development, differentiation, homeostasis, and reproduction.
Ying, Zhang, Maria L, Dufau
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Nuclear Ribosomal RNA Genes: ITS Region
2013Despite possible drawbacks (intraspecific polymorphisms and possible fungal contamination), sequencing of the ribosomal RNA gene ITS region remains one of the most popular nuclear sequences used for plant taxonomy and phylogeny. A protocol for PCR amplification and sequencing of this region using universal plant primers is provided.
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Gene repression by nuclear hormone receptors
Essays in Biochemistry, 2004Repression by nuclear hormone receptors (NHRs) plays an important role in development, immune response and cellular function. We review mechanisms of how NHRs act as repressors of gene transcription either by direct contact with basal transcription factors or through recruitment of cofactors and enzymic activities that modulate chromatin accessibility.
Udo, Moehren +2 more
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Nuclear inheritance of a gene affecting mitochondrial gene expression
Somatic Cell and Molecular Genetics, 1996Due to a deficiency in mitochondrial protein synthesis, Chinese hamster lung (CHL) cell mutant Gal- 32 does not grow in galactose or fructose. This report examines the nuclear or cytoplasmic inheritance of this single, recessive mutation. In a control experiment, fusion of Gal+TGSTK- cells with Gal- 32TGRTK+ cells resulted in tetraploid hybrids (as ...
Z A, Sherif +2 more
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Nuclear Gene Defects in Mitochondrial Disorders
2011Most mitochondrial cytopathies in infants are caused by mutations in nuclear genes encoding proteins targeted to the mitochondria rather than by primary mutations in the mitochondrial DNA. Over the past few years, the awareness of the number of disease-causing mutations in different nuclear genes has grown exponentially.
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Cytoplasmic modification of nuclear gene expression
Molecular and Cellular Biochemistry, 1983A review is presented on 1) the autonomous nature of mammalian cell cytoplasm and 2) the cytoplasmic modification of nuclear gene expression. Topics include a discussion of cytoplasmic suppression of tumorigenicity. It is proposed that alterations in DNA methylation patterns may be a possible mechanism to explain cytoplasmic modification of nuclear ...
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Nuclear Structure, Gene Expression and Development
Critical Reviews in Eukaryotic Gene Expression, 1999This article considers the extent to which features of nuclear structure are involved in the regulation of genome function. The recent renaissance in imaging technology has inspired a new determination to assign specific functions to nuclear domains or structures, many of which have been described as "factories" to express the idea that they coordinate
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