Going nuclear: gene family evolution and vertebrate phylogeny reconciled [PDF]
, 2002 Gene duplications have been common throughout vertebrate evolution, introducing paralogy and so complicating phylogenctic inference from nuclear genes.
James A. Cotton +6 more
core +4 more sources
Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases.
The Plant Journal, 2013 The unicellular green alga Chlamydomonas reinhardtii is a versatile model for fundamental and biotechnological research. A wide range of tools for genetic manipulation have been developed for this alga, but specific modification of nuclear genes is still
I. Sizova +4 more
semanticscholar +1 more source
Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations [PDF]
, 2005 Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins.
Bridger, JM +3 more
core +1 more source
The Contribution of Nuclear Compartmentalization to Gene Regulation [PDF]
Cell, 2002 Recent developments in live-cell imaging are challenging our stereotyped view of the fixed cell nucleus. The emerging picture is that nuclear processes may rely on a constant flow of molecules between dynamic compartments created by relatively immobile binding or assembly sites.
openaire +4 more sources
Regulation of NF-κB by PML and PML-RARα [PDF]
, 2017 Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar +8 more
core +1 more source
Nuclear translocation of Acinetobacter baumannii transposase induces DNA methylation of CpG regions in the promoters of E-cadherin gene. [PDF]
PLoS ONE, 2012 Nuclear targeting of bacterial proteins has emerged as a pathogenic mechanism whereby bacterial proteins induce host cell pathology. In this study, we examined nuclear targeting of Acinetobacter baumannii transposase (Tnp) and subsequent epigenetic ...
Dong Chan Moon +6 more
doaj +1 more source
Cell-free synthesis of cytochrome c [PDF]
, 1979 Cytochrome c is a peripheral membrane protein, attached to the cytoplasmic surface of the inner mito-chondrial membrane [l-4].
Blombäck +27 more
core +1 more source
Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics. [PDF]
, 2006 BackgroundTo accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos.ResultsUsing automated image analysis methods, we provide the ...
Biggin, Mark D +6 more
core +2 more sources
Assessing the preservation of cytosine methylation in ancient DNA from five prehistoric Native American populations [PDF]
, 2015 textCytosine methylation of CpG dinucleotides is an important epigenetic mark that regulates gene expression in humans. While methylation patterns in extant populations have been widely studied, few studies have attempted to analyze methylation in ...
Smith, Ricky Wayne Aldon
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source