Results 81 to 90 of about 13,614,081 (295)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Prompt gamma-rays from fast neutron capture in natNi
Ядерна фізика та енергетика, 2016 The yield of prompt γ-rays produced by interaction of 14 MeV neutrons with natNi was measured using the time-of-flight technique. A differential cross section from (n, xγ) reactions was unfolded from amplitude spectrum. Experimental results were compared
I. M. Kadenko +5 more
doaj
Angular momentum dependence of the nuclear level density parameter
, 2010 Dependence of nuclear level density parameter on the angular momentum and temperature is investigated in a theoretical framework using the statistical theory of hot rotating nuclei.
Kailas, S. +3 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Iraqi Journal of Physics, 2019 The experimental proton resonance data for the reaction P+48Ti have been used to calculate and evaluate the level density by employed the Gaussian Orthogonal Ensemble, GOE version of RMT, Constant Temperature, CT and Back Shifted Fermi Gas, BSFG models ...
Mahdi Hadi Jasim
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Vibrational Enhancement of Nuclear Level Density within Response Function Method [PDF]
, 2020 . The main results are summarized on the development of the response function method for a description of the vibrational state effect on nuclear level density. The enhancement factor is calculated and compared within different approaches. The results of
O M Gorbachenko, V A Plujko
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
EPJ Web of Conferences, 2017 Mean-field model calculations for nuclear structure theories are combined with the statistical Hauser-Feshbach code in order to improve predictive capabilities of nuclear reaction for experimentally unknown cross sections.
Kawano Toshihiko
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source