Results 91 to 100 of about 5,051,400 (380)

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Intermittent Bolus versus Continuous Infusion of Propofol for Deep Sedation during ABR/Nuclear Medicine Studies [PDF]

, 2017
Objective  A comparison of intermittent bolus (IB) versus continuous infusion of propofol for deep sedation. Material and Methods  A retrospective review of patients sedated for Auditory Brainstem Response (ABR)/nuclear medicine studies between September
Ahmed, Sheikh Sohail, Hicks, Shawn, Nitu, Mara, Slaven, James E.   +3 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Nuclear medicine and molecular imaging advances in the 21st century.

British Journal of Radiology, 2020
Currently, Nuclear Medicine has a clearly defined role in clinical practice due to its usefulness in many medical disciplines. It provides relevant diagnostic and therapeutic options leading to patients' healthcare and quality of life improvement. During
S. Vaz, Francisco P. M. Oliveira, K. Herrmann, P. Veit-Haibach   +3 more
semanticscholar   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part I: Cellular characterization [PDF]

, 2012
Embryonic stem cells derived from nuclear transfer embryos (ntESCs) are particularly valuable for regenerative medicine, as they are a patient-specific and histocompatible cell source for the treatment of varying diseases.
Csonka, Erika, Dinnyes, Andras, Hadlaczky, Gyula, Kobolak, Julianna, Mamo, Solomon, Rungsiwiwut, Ruttachuk, Ujhelly, Olga   +6 more
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Nuclear Medicine in the Philippines: A Glance at the Past, a Gaze at the Present, and a Glimpse of the Future [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2016
While the introduction of radioactive tracers in the study of metabolic pathways has been well-documented in clinical thyroidology as early as 1924, the widespread utilization in other clinical specialties has been hampered by slow developments in ...
Patricia Bautista, Teofilo San Luis, Jr.
doaj   +1 more source

Global Issues of Radiopharmaceutical Access and Availability: A Nuclear Medicine Global Initiative Project

Journal of Nuclear Medicine, 2020
The Nuclear Medicine Global Initiative was formed in 2012 by 13 international organizations to promote human health by advancing the field of nuclear medicine and molecular imaging by supporting the practice and application of nuclear medicine. The first
C. Cutler, E. Bailey, Vijay Kumar, S. Schwarz, H. Bom, J. Hatazawa, D. Paez, P. Orellana, L. Louw, F. Mut, H. Kato, A. Chiti, S. Frangos, F. Fahey, G. Dillehay, S. Oh, D. Lee, S. Lee, Rodolfo Nuñez-Miller, G. Bandhopadhyaya, P. Pradhan, A. Scott   +21 more
semanticscholar   +1 more source

Nuclear Physics for Cultural Heritage [PDF]

, 2016
Nuclear physics applications in medicine and energy are well known and widely reported. Less well known are the many important nuclear and related techniques used for the study, characterization, assessment and preservation of cultural heritage.
The Nuclear Physics Division of the European Physical Society
core  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source