Results 51 to 60 of about 6,917,354 (302)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

[18F]FDG WBC labelled PET/CT for the diagnosis of infectious disease: initial experience in a tertiary centre

EJNMMI Research
Background Labelling WBC with [18F]FDG may be an alternative for accurate infection diagnosis, combining the excellent sensitivity of [18F]FDG with the excellent specificity of WBC-labelled SPECT/CT.
Christel Hermann Kamani, Julien Costes, Maxime Panchaud, Kilian Casagrande, Giorgio Treglia, Mario Jreige, Marie Nicod Lalonde, Niklaus Schaefer, Judith Delage, John O. Prior   +9 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Machine Learning in the Nuclear Medicine: Part 1-Introduction

, 2019
This research was originally published in JNM. Uribe, C.F., Mathotaarachchi, S., Gaudet, V., Smith, K.C, Rosa-Neto, P., Benard, F., Black, S.E. & Zukotynski, K. Machine Learning in Nuclear Medicine: Part 1 - Introduction. J Nucl Med.
Gaudet, Vincent C., Benard, Francois, Mathotaarachchi, Sulantha, Black, Sandra E., Smith, Kenneth C., Rosa-Neto, Pedro, Zukotynski, Katherine, Uribe, Carlos F.   +7 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes

EJNMMI Research, 2018
Background 18F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an early stage.
Martijn Devrome, Donatienne Van Weehaeghe, Joke De Vocht, Philip Van Damme, Koen Van Laere, Michel Koole   +5 more
doaj   +1 more source

EANM/SNMMI guideline for 18F-FDG use in inflammation and infection. [PDF]

, 2013
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology and practical application of nuclear medicine. Its 16,000 members are physicians,
Chiti, Arturo, Delbeke, Dominique, Donohoe, Kevin J., Buscombe, John, Christian, Paul E., Christian PE, SIGNORE, Alberto, Jamar, Francois, Donohoe KJ, Martin Comin J, Jamar F, Chiti A, Delbeke D, Buscombe, John Richard, Buscombe J, Israel, Ora, Martin-Comin, Josep, Israel O   +17 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Nuclear Medicine Imaging in Pediatric Neurology.

, 2016
Nuclear medicine imaging can provide important complementary information in the management of pediatric patients with neurological diseases. Pre-surgical localization of the epileptogenic focus in medically refractory epilepsy patients is the most common
Atay Kapucu, Lütfiye Özlem, Akdemir, Ümit Özgür, Kapucu, LÜTFİYE ÖZLEM   +2 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source