Results 71 to 80 of about 6,917,354 (302)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of motion and white matter hyperintensities on reference region based ¹⁸F-SynVesT-1 PET quantification in Alzheimer’s disease and healthy volunteers

EJNMMI Research
Background 18F-SynVesT-1 is a PET tracer targeting synaptic vesicle protein 2A, a surrogate marker of synaptic density. Simplified quantification using pseudo-reference regions such as the centrum semiovale (CSO) or whole cerebellum (CER) has previously ...
Charles Carron, Simon Noë, Greet Vanderlinden, Michel Koole, Georg Schramm, Koen Van Laere   +5 more
doaj   +1 more source

Initial experience with a SiPM-based PET/CT scanner: influence of acquisition time on image quality

EJNMMI Physics, 2018
Background A newly introduced PET/CT scanner (Discovery Meaningful Insights—DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this study, we investigated the impact
Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir, Andrei Iagaru   +7 more
doaj   +1 more source

Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology

European Journal of Hybrid Imaging, 2020
The use of hybrid systems is increasingly growing in Europe and this is progressively important for the final result of diagnostic tests. As an integral part of the hybrid imaging system, computed tomography (CT) plays a crucial role in myocardial ...
Luca Camoni, Andrea Santos, Marieclaire Attard, Marius Ovidiu Mada, Agata Karolina Pietrzak, Sonja Rac, Sebastijan Rep, Christelle Terwinghe, Pedro Fragoso Costa, on behalf of the Technologist Committee of the European Association of Nuclear Medicine (EANM)   +9 more
doaj   +1 more source

The Necessity of Using Heparin in an UltraTag™ RBC Kit when Tagging Blood for a Nuclear Medicine Study

, 2016
The purpose of this research was to evaluate the need to use heparin when preparing an UltraTag red blood cell (RBC) kit for a nuclear medicine study.
Nielsen, Cybil J., Brehl, Nicholas C., Pigmon, Sarah R., Weatherman, Kara D.   +3 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assessment of Viable Myocardium with Nuclear Imaging

, 2009
Nuclear cardiac imaging has been widely used to assess viable myocardium in patients with ischemic heart disease, The assessment of viable myocardium is important in selecting patients who will be benefit from revascularization.
강원준
core  

Monte Carlo Simulation of Nuclear Medicine Imaging Systems

, 2022
This chapter describes the use of the Monte Carlo method to simulate nuclear medicine imaging systems, mainly the scintillation camera – SPECT (Single-Photon Emission Computed Tomography) and PET (Positron Emission Tomography) – systems that are major ...
Ljungberg, Michael,, Sarrut, David, Lund University.   +2 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source