Results 81 to 90 of about 903,366 (305)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Discovering nuclear models from symbolic machine learning

Communications Physics
Numerous phenomenological nuclear models have been proposed to describe specific observables within different regions of the nuclear chart. However, developing a unified model that describes the complex behavior of all nuclei remains an open challenge ...
Jose M. Munoz, Silviu M. Udrescu, Ronald F. Garcia Ruiz   +2 more
doaj   +1 more source

Nonextensive critical effects in relativistic nuclear mean field models*

EPJ Web of Conferences, 2011
We present a possible extension of the usual relativistic nuclear mean field models widely used to describe nuclear matter towards accounting for the influence of possible intrinsic fluctuations caused by the environment.
Rożynek J., Wilk G.
doaj   +1 more source

From Containing the Atom to Mitigating Residual Risk: The German Imaginary of Nuclear Emergency Preparedness

Atmosphere, 2020
Grounded in a social scientific research approach, the present case study traces the shift in the German nuclear regulatory culture from prevention to preparedness, the latter of which builds upon decision support systems for nuclear emergency management.
Tudor B. Ionescu
doaj   +1 more source

GEANT4 : a simulation toolkit [PDF]

, 2005
Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits.
Arce, P., Tanaka, S., Rybin, A., Degtyarenko, P., Brunengo, A., Sulkimo, J., Chytracek, R., Garelli, S., Pia, M.G., Boudreau, J., Stoecker, H., Agostinelli, S., Asai, M., Burkhardt, H., Araujo, H., Takahata, M., Grichine, V., Zschiesche, D., González, I., Yamada, T., Scherer, Stefan, Lamanna, E., Cosmo, G., Starkov, N., Wander, W., Tropeano, M., Kawabata, M., Kodama, Takeshi, Ohtsubo, K., Tcherniaev, E., Kimura, Atsushi, Lefebure, V., Behner, F., Longo, F., Truscott, P., Jones, F.W., Wellisch, J.P., O'Neale, S., Banerjee, S., Depaola, G., Liendl, M., Urban, P., Feliciello, Alessandro, Chauvie, S., Kanaya, N., Pfeiffer, Andreas, Foppiano, F., Weber, H., Paech, K., Ranjard, F., Allison, J., Greeniaus, G., Nishimura, T., Uno, H., Hasui, H., Greiner, W., Giani, S., Guatelli, S., Hashimoto, K., Nieminen, P., Kodama, T., Sirotenko, V., Okamura, M., Safai Tehrani, E., Kelner, S., Ferguson, C., Kawaguti, M., Pfeiffer, A., Howard, A., Smith, D., Greiner, Walter, Kallenbach, J., Kossov, M., Sadilov, S., Minamimoto, K., Lei, F., Williams, D.C., Yoshida, H., Verderi, M., Kawabata, Y., Axen, D., Gracia Abril, G., Ivanchenko, V., Fesefeldt, H., Heikkinen, A., O’Neale, S., Kokoulin, R., Lara, V., Folger, G., Dell’Acqua, A., Gómez Cadenas, J.J., Maire, M., Kurashige, H., Nagamatu, M., Dietrich, D., Enami, R., Sawada, Y., Scherer, S., Giannitrapani, R., Medernach, E., Amako, K., Chuma, J., Santin, G., Broglia, L., Sei, S., Nartallo, R., Apostolakis, J., Urban, L., Barrand, G., Magni, S., Dell'Acqua, A., Wenaus, T., Stöcker, Horst, Wright, D., Morita, Y., Lockman, W., Gumplinger, P., Bellagamba, L., Savvas, N., Mora de Freitas, P., Di Salvo, E., Oohata, Y., Perl, J., Cooperman, G., Hamatsu, R., Gibin, D., Kent, P., Feliciello, A., Murakami, K., Grossheim, A., Walkden, A., Forti, A., Johnson, A., Kimura, A., Lampén, T., Sasaki, T.   +135 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Concepts for a modular nuclear powered containership [PDF]

, 2013
With the amendments to the MARPOL Annex VI regulations to control NOx and SOx emissions, fuel prices will increase considerably by 2020. Coupled with depleting fossil fuel reserves and owners’ perceptions on their environmental impact, fossil fuel ...
Hirdaris, Spyros, Turnock, Stephen R., Shenoi, R. Ajit, Gravina, Jonathan, Blake, James I.R.   +4 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source