Results 121 to 130 of about 699,479 (309)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Emerging nuclear states and the challenge of non-proliferation

open access: yes, 2008
Emerging nuclear states and the challenge of non ...
J Boutin (15873647)
core  

Interpreting the Nuclear Non-proliferation Treaty /

open access: yes, 2017
The 1968 Nuclear Non-Proliferation Treaty is one of the most controversial instruments in international law. This text argues that countries with nuclear weapons misrepresent the Treaty to prevent other states from developing peaceful nuclear energy ...
Joyner, Daniel.
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Nuclear Non-Proliferation Treaty Issues of compliance and implementation

open access: yes, 1997
SIGLEAvailable from British Library Document Supply Centre-DSC:4584.0336(9) / BLDSC - British Library Document Supply CentreGBUnited ...
Programme for Promoting Nuclear Non-Proliferation, Southampton (United Kingdom)   +1 more
core  

Africa’s role in global nuclear non-proliferation

open access: yes, 2022
The post-WWII nuclear era coincided with the spread of African decolonisation. United by opposition to French nuclear tests in the Sahara, the unique combination of decolonisation and denuclearisation impacted the trajectory of nuclear non-proliferation ...
Mpofu-Walsh, Sizwe
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

On New Interest in Nuclear Deterrence Capabilities in Germany

open access: yesСравнительная политика
As nuclear proliferation risks grow, researchers are focusing on countries that were hardly associated with the problem earlier. Geopolitical developments and change in transatlantic relations are forcing European countries to overhaul their military ...
A. E. Pavlov
doaj   +1 more source

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