Results 111 to 120 of about 948,791 (303)

Assessing the nuclear weapons proliferation risks in nuclear energy newcomer countries: The case of small modular reactors

Nuclear Engineering and Technology
While several nuclear energy newcomer (NEN) countries have shown interest in small modular reactors (SMRs) as a potential energy source, this interest can generate new uncertainties regarding future nuclear weapons proliferation risks.
Philseo Kim, Sunil S. Chirayath
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Review of the Nuclear Non-Proliferation Treaty: A Practitioner’s Perspective

Journal for Peace and Nuclear Disarmament
The 1970 Nuclear Non-Proliferation Treaty (NPT) has proven remarkably resilient across its long history, reflecting broad agreement among states that the further spread of nuclear weapons will increase the risks of nuclear war and global instability ...
Adam M. Scheinman
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Türkiye’s Nuclear Nonproliferation Policy: History and Prospects

Vestnik RUDN. International Relations
The relevance of the topic lies in the increasing role of nuclear weapons in international relations, both as a political and military tool and as a means of exerting influence and engaging in confrontation.
Tatyana V. Kashirina, Veronika V. Tsibenko   +1 more
doaj   +1 more source

What Would Zero Look Like? A Treaty for the Abolition of Nuclear Weapons [PDF]

, 2014
Nuclear disarmament-the comprehensive, universal, and permanent abolition of all nuclear weapons, pursuant to a verifiable, legally binding international agreement-has long been one of the most ambitious, controversial, and urgent items on the agenda for
Koplow, David A
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Long term remote reactor power and fuel composition monitoring using antineutrinos

Physics Letters B
Electron antineutrinos are emitted in the decay chains of the fission products inside a reactor core and could be used for remote monitoring of nuclear reactors.
I. Alekseev, V. Belov, A. Bystryakov, M. Danilov, D. Filosofov, M. Fomina, P. Gorovtsov, Ye. Iusko, S. Kazartsev, V. Khvatov, S. Kiselev, A. Kobyakin, A. Krapiva, A. Kuznetsov, I. Machikhiliyan, N. Mashin, D. Medvedev, V. Nesterov, D. Ponomarev, I. Rozova, N. Rumyantseva, V. Rusinov, A. Salamatin, E. Samigullin, Ye. Shevchik, M. Shirchenko, Yu. Shitov, N. Skrobova, D. Svirida, E. Tarkovsky, E. Yakushev, I. Zhitnikov, A. Yakovleva, D. Zinatulina   +33 more
doaj   +1 more source

Export Control Regulations in the United Arab Emirates - Comparative Analysis with the United Kingdom [PDF]

, 2001
Governments across the world appreciate the need for checks on the transfer or exportation of commodities, information, software, and technology considered of strategic value.
Malkawi, Bashar H.
core