Results 91 to 100 of about 948,791 (303)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

“A verification cotton” between crystals: the Discussions about Regional Nuclear Verification Mechanisms in South America and the Creation of the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) (1967-1992) [PDF]

Revista Brasileira de Política Internacional
The Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) was established in 1991. It marked the culmination of a rapprochement process that began in the 1980s, as two former adversaries transitioned into cooperative partners.
Leonardo Bandarra
doaj   +1 more source

Civil society legitimacy and nuclear non-proliferation [PDF]

During recent years, civil society legitimacy has generated a growing interest in scholarly research. The present article therefore proposes four normative criteria, namely, independence, transparency, participation, and inclusion, in order to start ...
Kissling, Claudia
core  

North Korea and the Non-proliferation Regime [PDF]

, 2009
In this review of the implications of North Korea’s behaviour during 2009 on the Non-proliferation Regime, it is stressed that if North Korea cannot be deterred from its nuclear ambitions this will deliver a serious blow to the international non ...
Reiss, Mitchell B.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

GLAND CELLS IN HYDRA [PDF]

, 1986
The proliferative capacity of gland cells in Hydra attenuata was investigated. The results indicate that both gland cell proliferation and interstitial cell differentiation to gland cells contribute to the maintenance of the whole population.
David, Charles N., Schmidt, Tobias
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nuclear Energy Security: Emerging Trends and Pakistan

Policy Perspectives, 2016
The demand for nuclear energy has increased in recent years mainly in the developing countries of the Asia-Pacific. Despite the Japanese (Fukushima) nuclear power plant accident in 2011, the nuclear power industry is expected to inflate exponentially in ...
Rizwana Abbasi
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Nuclear safeguards: Technology, challenges, and future perspectives

Alexandria Engineering Journal
This comprehensive review paper delves into the multifaceted aspects of nuclear safeguards, emphasizing their indispensable role in upholding global security and preventing the illicit use of nuclear materials. Offering a fresh perspective on the nuclear
Muhammad Zubair, Ronak Radkiany, Yumna Akram, Eslam Ahmed   +3 more
doaj   +1 more source