Results 91 to 100 of about 12,386,479 (292)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Replication data for: Nuclear Assistance Does Not Cause Nuclear Proliferation

, 2010
This article shows that Matthew Kroenig (2009)’s evidence that nuclear assistance increases states’ probability of acquiring nuclear weapons is overturned when more comprehensive indicators of state capacity are taken into account.
Derick Bowen, Abdul Tariq, Anna Weisfeiler
core   +1 more source

Nuclear safeguards: Technology, challenges, and future perspectives

Alexandria Engineering Journal
This comprehensive review paper delves into the multifaceted aspects of nuclear safeguards, emphasizing their indispensable role in upholding global security and preventing the illicit use of nuclear materials. Offering a fresh perspective on the nuclear
Muhammad Zubair, Ronak Radkiany, Yumna Akram, Eslam Ahmed   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Use of the Internet and ICT to Monitor Uranium Enrichment Programmes and Contrast Nuclear Proliferation

, 2013
The speech illustrated the possibility of using cyberspace to counter nuclear proliferation. In particular, the issue was discussed in relation to the (un)lawful status of cyberspace operations under international ...
Annachiara Rotondo
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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Assessing the nuclear weapons proliferation risks in nuclear energy newcomer countries: The case of small modular reactors

Nuclear Engineering and Technology
While several nuclear energy newcomer (NEN) countries have shown interest in small modular reactors (SMRs) as a potential energy source, this interest can generate new uncertainties regarding future nuclear weapons proliferation risks.
Philseo Kim, Sunil S. Chirayath
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

U.S. support for peaceful nuclear cooperation.

, 2000
"April 2000"--P.
United States. Non-Proliferation Bureau. Multilateral Nuclear Affairs.
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