Results 81 to 90 of about 12,386,479 (292)

“A verification cotton” between crystals: the Discussions about Regional Nuclear Verification Mechanisms in South America and the Creation of the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) (1967-1992) [PDF]

Revista Brasileira de Política Internacional
The Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) was established in 1991. It marked the culmination of a rapprochement process that began in the 1980s, as two former adversaries transitioned into cooperative partners.
Leonardo Bandarra
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Treaty on the Prohibition of Nuclear Weapons: Strengths, Weaknesses and Current Status

Journal for Peace and Nuclear Disarmament
This commentary offers an analysis of the Treaty on the Prohibition of Nuclear Weapons (TPNW), its strengths, weaknesses, relationship to other agreements as well as recent updates.
Jean Krasno, Elisabeth Szeli
doaj   +1 more source

Revisitando a política nuclear dos governos de Richard Nixon e de Gerald Ford (1969-1977)

Revista Conjuntura Austral, 2018
Este artigo examina a política nuclear das administrações de Richard Nixon e Gerald Ford, por meio da análise de fontes primárias e secundárias sobre principais fatores internacionais e domésticos que as influenciaram.
Leonardo Carvalho Leite Azeredo Bandarra
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

AID PROHIBITION AS A TOOL OF THE U.S. FOREIGN POLICY: DE JURE AND DE FACTO

Vestnik MGIMO-Universiteta, 2019
The United States is indisputable global leader in utilizing tools of economic statecraft to secure national interests both through rewarding foreign countries for policies conforming the Washington interests and through punishing them for a deviant ...
V. I. Bartenev
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Nuclear Energy Security: Emerging Trends and Pakistan

Policy Perspectives, 2016
The demand for nuclear energy has increased in recent years mainly in the developing countries of the Asia-Pacific. Despite the Japanese (Fukushima) nuclear power plant accident in 2011, the nuclear power industry is expected to inflate exponentially in ...
Rizwana Abbasi
doaj   +1 more source