Results 61 to 70 of about 579,031 (266)
Investigation of nuclear material using a compact modified uniformly redundant array gamma camera
Nuclear Engineering and Technology, 2018 We developed a compact gamma camera based on a modified uniformly redundant array coded aperture to investigate the position of a UO2 pellet emitting characteristic X-rays (98.4 keV) and γ-rays (185.7 keV).
Taewoong Lee, Sung-Woo Kwak, Wonho Lee
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Em nome da autonomia e do desenvolvimento
Meridiano 47, 2017 The objective is to examine the positions adopted by Brazil on nuclear non-proliferation, disarmament and peaceful uses of nuclear energy in the beginning of this century.
Diego Santos Vieira de Jesus
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The global nuclear order and the crisis of the nuclear non-proliferation regime: Taking stock and moving forward. [PDF]
Z Friedens Konfliktforsch, 2021 Baldus J, Müller H, Wunderlich C.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Multilateral Nuclear Approaches
Meridiano 47, 2017 Calls for Multilateral Nuclear Approaches (MNAs) have been raised due to growing risks that the expansion of the nuclear power sector poses to a strained international non-proliferation regime.
Rodrigo Moreira Penna
doaj
The Treaty on the Prohibition of Nuclear Weapons: Strengths, Weaknesses and Current Status
Journal for Peace and Nuclear DisarmamentThis commentary offers an analysis of the Treaty on the Prohibition of Nuclear Weapons (TPNW), its strengths, weaknesses, relationship to other agreements as well as recent updates.
Jean Krasno, Elisabeth Szeli
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source