Results 51 to 60 of about 12,386,479 (292)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Nuclear Non-proliferation Treaty (NPT) [PDF]

, 2011
The Treaty on the Non-Proliferation of Nuclear Weapons opened for signatories on 1 July 1968. It came into force on 5 March 1970. A review meeting takes place every five years. The initial treaty was limited to a 25-year term but it was extended indefinitely in 1995.
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

What Should the International Non-Proliferation Regime Look Like Today and Over the Next 10 to 20 Years?

Journal for Peace and Nuclear Disarmament
Frustration over the lack of progress in nuclear disarmament under the Nuclear Non-Proliferation Treaty (NPT) led to the creation of the Treaty on the Prohibition of Nuclear Weapons (TPNW). On the other hand, there is criticism that the TPNW has fostered
Andreas Persbo, Kseniia Pirnavskaia
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation [PDF]

, 2008
Shape-dependent local differentials in cell proliferation are considered to be a major driving mechanism of structuring processes in vivo, such as embryogenesis, wound healing, and angiogenesis.
Farré, Ramon, Roca-Cusachs Soulere, Pere, Farré Ventura, Ramon, Samitier, Josep, Alcaraz Casademunt, Jordi, Roca-Cusachs, Pere, Samitier i Martí, Josep, Navajas, Daniel, Sunyer, Raimon, Navajas Navarro, Daniel, Alcaraz, Jordi   +10 more
core   +1 more source

Global Zero Regime: Need to Transition from Heteronomous to Autonomous Systems

Journal for Peace and Nuclear Disarmament
If nuclear abolition was to be achieved, then a shift would be required from an international nuclear non-proliferation regime that limits the number of nuclear-armed states to a global zero regime that prevents the re-emergence of nuclear-armed states ...
Kazuko Hikawa
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Emerging Powers and the Nuclear Non-Proliferation and Disarmament Regime. Security Policy Brief 27, September 2011 [PDF]

, 2011
In this Policy Brief, Tom Sauer looks at the ambivalent position of emerging powers vis-à-vis nuclear non-proliferation and what this eventually means for the ...
Sauer, Tom
core   +1 more source