Results 51 to 60 of about 948,791 (303)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Sustainable nuclear non-proliferation. Case-study: Iran
Intergenerational Justice ReviewSustainable nuclear non-proliferation is only possible in a world without nuclear weapons. As long as there are nuclear weapons, the odds are that nuclear proliferation will happen, despite the existence of a comprehensive nuclear non-proliferation ...
Tom Sauer
doaj +1 more source
Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients [PDF]
, 2016 Background: 8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs).
Aitchison, Michael +9 more
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Civil society legitimacy and nuclear non-proliferation [PDF]
, 2008 During recent years, civil society legitimacy has generated a growing interest in scholarly research. The present article therefore proposes four normative criteria, namely, independence, transparency, participation, and inclusion, in order to start ...
Kissling, Claudia
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Journal for Peace and Nuclear DisarmamentFrustration over the lack of progress in nuclear disarmament under the Nuclear Non-Proliferation Treaty (NPT) led to the creation of the Treaty on the Prohibition of Nuclear Weapons (TPNW). On the other hand, there is criticism that the TPNW has fostered
Andreas Persbo, Kseniia Pirnavskaia
doaj +1 more source
The importance of Nuclear Weapons Free Zones [PDF]
, 2005 Some say that it is nothing but an illusion to think of a world totally without nuclear weapons. This might be true. Nonetheless, although the total abolition of nuclear weapons seems, at present, to be quite difficult, promoting Nuclear Weapons Free ...
Mukai, Wakana
core
Clarifying Pokhran-II in a multilinguistic setting [PDF]
, 2018 In May of 1998, India conducted its second nuclear test after a period of 24 years. This second test, known as Pokhran-II, caught the world by surprise and 17 days later it was followed by Pakistan’s first test of a nuclear device.
Gallacher, Hunter Andrew
core +1 more source