Results 51 to 60 of about 699,479 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

What Should the International Non-Proliferation Regime Look Like Today and Over the Next 10 to 20 Years?

Journal for Peace and Nuclear Disarmament
Frustration over the lack of progress in nuclear disarmament under the Nuclear Non-Proliferation Treaty (NPT) led to the creation of the Treaty on the Prohibition of Nuclear Weapons (TPNW). On the other hand, there is criticism that the TPNW has fostered
Andreas Persbo, Kseniia Pirnavskaia
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation

, 2008
Shape-dependent local differentials in cell proliferation are considered to be a major driving mechanism of structuring processes in vivo, such as embryogenesis, wound healing, and angiogenesis.
Farré, Ramon, Roca-Cusachs Soulere, Pere, Farré Ventura, Ramon, Samitier, Josep, Alcaraz Casademunt, Jordi, Roca-Cusachs, Pere, Samitier i Martí, Josep, Navajas, Daniel, Sunyer, Raimon, Navajas Navarro, Daniel, Alcaraz, Jordi   +10 more
core   +1 more source

Global Zero Regime: Need to Transition from Heteronomous to Autonomous Systems

Journal for Peace and Nuclear Disarmament
If nuclear abolition was to be achieved, then a shift would be required from an international nuclear non-proliferation regime that limits the number of nuclear-armed states to a global zero regime that prevents the re-emergence of nuclear-armed states ...
Kazuko Hikawa
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cooperative Security in the Post-Cold War International System: The Cooperative Threat Reduction (CTR) Process [PDF]

, 2004
The thesis explores cooperative security efforts between the United States and Russia in the framework of the Cooperative Threat Reduction (CTR) Programme and other non-proliferation programmes, which were established in the aftermath of the Soviet ...
Kassenova, Togzhan O
core  

The AUKUS Alliance and its Implications on the Non-Proliferation Treaty

BTTN Journal, 2022
A new three-pronged security pact was signed in September 2021 between the United States, the United Kingdom, and Australia, allowing Australia to acquire nuclear-propelled submarines and advance technological sharing on a variety of fronts, including ...
Sikandar Azam Khan
doaj