Results 51 to 60 of about 579,031 (266)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Research & Politics, 2015 In the literature on nuclear proliferation, some argue that further proliferation decreases interstate conflict, some say that it increases interstate conflict, and others indicate a non-linear relationship between these two factors.
Akisato Suzuki
doaj +1 more source
Revisitando a política nuclear dos governos de Richard Nixon e de Gerald Ford (1969-1977)
Revista Conjuntura Austral, 2018 Este artigo examina a política nuclear das administrações de Richard Nixon e Gerald Ford, por meio da análise de fontes primárias e secundárias sobre principais fatores internacionais e domésticos que as influenciaram.
Leonardo Carvalho Leite Azeredo Bandarra
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The AUKUS Alliance and its Implications on the Non-Proliferation Treaty
BTTN Journal, 2022 A new three-pronged security pact was signed in September 2021 between the United States, the United Kingdom, and Australia, allowing Australia to acquire nuclear-propelled submarines and advance technological sharing on a variety of fronts, including ...
Sikandar Azam Khan
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
AID PROHIBITION AS A TOOL OF THE U.S. FOREIGN POLICY: DE JURE AND DE FACTO
Vestnik MGIMO-Universiteta, 2019 The United States is indisputable global leader in utilizing tools of economic statecraft to secure national interests both through rewarding foreign countries for policies conforming the Washington interests and through punishing them for a deviant ...
V. I. Bartenev
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Nuclear Disarmament and Non-Proliferation [PDF]
, 2010 This book examines the current debate on nuclear non-proliferation and disarmament, notably the international non-proliferation regime and how to implement its disarmament provisions. Discussing the requirements of a new international consensus on nuclear disarmament and non-proliferation, this book builds on the three pillars of the nuclear non ...
openaire +4 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source