Results 71 to 80 of about 12,386,479 (292)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Em nome da autonomia e do desenvolvimento
Meridiano 47, 2017 The objective is to examine the positions adopted by Brazil on nuclear non-proliferation, disarmament and peaceful uses of nuclear energy in the beginning of this century.
Diego Santos Vieira de Jesus
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Atom Indonesia, 2007 In the midst of nuclear countries and non-nuclear countries in the framework of non-proliferation and disarmament, Indonesia has played an important role.
S. Sriwidjaja
doaj +1 more source
The global nuclear order and the crisis of the nuclear non-proliferation regime: Taking stock and moving forward. [PDF]
Z Friedens Konfliktforsch, 2021 Baldus J, Müller H, Wunderlich C.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The European Union's Nuclear Non-proliferation Policy
This book looks at European Union (EU) attempts to manage the risks associated with nuclear non-proliferation and assesses its performance and external challenges.
Herrera, Manuel
core +1 more source
NATO's Role in Nuclear Non-Proliferation and Arms Control: A (Critical) History
, 2021 This paper looks at the interaction between the Atlantic Alliance and the main arms-control negotiations of the nuclear age. The first part is dedicated to the role the Alliance played in the arms-control and non-proliferation process that shaped the ...
Nuti, Leopoldo
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Multilateral Nuclear Approaches
Meridiano 47, 2017 Calls for Multilateral Nuclear Approaches (MNAs) have been raised due to growing risks that the expansion of the nuclear power sector poses to a strained international non-proliferation regime.
Rodrigo Moreira Penna
doaj