Results 101 to 110 of about 12,386,479 (292)

Review of the Nuclear Non-Proliferation Treaty: A Practitioner’s Perspective

Journal for Peace and Nuclear Disarmament
The 1970 Nuclear Non-Proliferation Treaty (NPT) has proven remarkably resilient across its long history, reflecting broad agreement among states that the further spread of nuclear weapons will increase the risks of nuclear war and global instability ...
Adam M. Scheinman
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The Aiken factor: Ireland and the invention of nuclear non-proliferation [PDF]

For many, the former Irish Minister for External Affairs Frank Aiken is, with good reason, synonymous with the Nuclear Non-Proliferation Treaty’s (NPT) origins.
O'Driscoll, Mervyn
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Long term remote reactor power and fuel composition monitoring using antineutrinos

Physics Letters B
Electron antineutrinos are emitted in the decay chains of the fission products inside a reactor core and could be used for remote monitoring of nuclear reactors.
I. Alekseev, V. Belov, A. Bystryakov, M. Danilov, D. Filosofov, M. Fomina, P. Gorovtsov, Ye. Iusko, S. Kazartsev, V. Khvatov, S. Kiselev, A. Kobyakin, A. Krapiva, A. Kuznetsov, I. Machikhiliyan, N. Mashin, D. Medvedev, V. Nesterov, D. Ponomarev, I. Rozova, N. Rumyantseva, V. Rusinov, A. Salamatin, E. Samigullin, Ye. Shevchik, M. Shirchenko, Yu. Shitov, N. Skrobova, D. Svirida, E. Tarkovsky, E. Yakushev, I. Zhitnikov, A. Yakovleva, D. Zinatulina   +33 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Finland and Nuclear Non-Proliferation : Fifty years of implementing the Nuclear Non-Proliferation Treaty [PDF]

, 2020
The research paper by Petri Paju, Adjunct Professor at the University of Turku, explores the methods of and motives for Finns implementing the Nuclear Non-Proliferation Treaty from the 1960s onwards.
Paju, Petri
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Türkiye’s Nuclear Nonproliferation Policy: History and Prospects

Vestnik RUDN. International Relations
The relevance of the topic lies in the increasing role of nuclear weapons in international relations, both as a political and military tool and as a means of exerting influence and engaging in confrontation.
Tatyana V. Kashirina, Veronika V. Tsibenko   +1 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source