Results 101 to 110 of about 699,479 (309)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

A Unified Risk-Informed Framework to Assess the Proliferation Risk and License the Proliferation Performace of Nuclear Energy

, 2011
In order to strengthen the current non-proliferation regime it is necessary to guarantee high standards of security for the sites that use, store, produce, or reprocess special nuclear materials (SNM).
d'Oro, Edoardo Cavalieri, Golay, Michael J.   +1 more
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State-of-the-Art Report [Elektronisk resurs] : Prepared by Working Group 4: Technical nuclear non-proliferation and safeguards under the Alva Myrdal Centre for nuclear disarmament

, 2022
The Alva Myrdal Centre for nuclear disarmament (AMC) was established in 2021. AMC consists of six working Groups, and one of them - Working Group 4 - is called Technical nuclear non-proliferation and safeguards.
Österlund, Michael,, Kelley, Robert E.,, Mishra, Vaibhav,, Gustavsson, Cecilia,, Grape, Sophie,, Andersson, Peter,, Göök, Alf,, Branger, Erik,, Fedchenko, Vitaly,, Preston, Markus,   +9 more
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Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Assessing the nuclear weapons proliferation risks in nuclear energy newcomer countries: The case of small modular reactors

Nuclear Engineering and Technology
While several nuclear energy newcomer (NEN) countries have shown interest in small modular reactors (SMRs) as a potential energy source, this interest can generate new uncertainties regarding future nuclear weapons proliferation risks.
Philseo Kim, Sunil S. Chirayath
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Argentina-Brazil nuclear non-proliferation initiatives

, 1994
SIGLEGBUnited ...
Programme for Promoting Nuclear Non-Proliferation, Southampton (United Kingdom), Redick, J.R   +1 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Germany, Europe and nuclear non-proliferation

, 1991
SIGLEGBUnited ...
Programme for Promoting Nuclear Non-Proliferation, Southampton (United Kingdom), Koetter, W., Mueller, H   +2 more
core