Results 71 to 80 of about 315,285 (314)

Quantum mechanics principle and other physics principles involved in light and laser therapy

Journal of Cosmetic Medicine
Laser and light therapies have revolutionized the field of cosmetic medicine because of their ability to treat a range of dermatological conditions safely and effectively.
Cheuk Hung Lee, Kar Wai Alvin Lee, Kwin Wah Chan   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Fundamental physics studies in time domain and multi-messenger astronomy

Frontiers in Astronomy and Space Sciences
The era of ime domain and multi-messenger astronomy is not only leading to the development of a much broader set of detectors and instruments for astrophysical observations, but is also providing the means for astronomy to tie directly to cutting-edge ...
Chris Fryer
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

GEANT4 : a simulation toolkit [PDF]

, 2005
Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits.
Arce, P., Tanaka, S., Rybin, A., Degtyarenko, P., Brunengo, A., Sulkimo, J., Chytracek, R., Garelli, S., Pia, M.G., Boudreau, J., Stoecker, H., Agostinelli, S., Asai, M., Burkhardt, H., Araujo, H., Takahata, M., Grichine, V., Zschiesche, D., González, I., Yamada, T., Scherer, Stefan, Lamanna, E., Cosmo, G., Starkov, N., Wander, W., Tropeano, M., Kawabata, M., Kodama, Takeshi, Ohtsubo, K., Tcherniaev, E., Kimura, Atsushi, Lefebure, V., Behner, F., Longo, F., Truscott, P., Jones, F.W., Wellisch, J.P., O'Neale, S., Banerjee, S., Depaola, G., Liendl, M., Urban, P., Feliciello, Alessandro, Chauvie, S., Kanaya, N., Pfeiffer, Andreas, Foppiano, F., Weber, H., Paech, K., Ranjard, F., Allison, J., Greeniaus, G., Nishimura, T., Uno, H., Hasui, H., Greiner, W., Giani, S., Guatelli, S., Hashimoto, K., Nieminen, P., Kodama, T., Sirotenko, V., Okamura, M., Safai Tehrani, E., Kelner, S., Ferguson, C., Kawaguti, M., Pfeiffer, A., Howard, A., Smith, D., Greiner, Walter, Kallenbach, J., Kossov, M., Sadilov, S., Minamimoto, K., Lei, F., Williams, D.C., Yoshida, H., Verderi, M., Kawabata, Y., Axen, D., Gracia Abril, G., Ivanchenko, V., Fesefeldt, H., Heikkinen, A., O’Neale, S., Kokoulin, R., Lara, V., Folger, G., Dell’Acqua, A., Gómez Cadenas, J.J., Maire, M., Kurashige, H., Nagamatu, M., Dietrich, D., Enami, R., Sawada, Y., Scherer, S., Giannitrapani, R., Medernach, E., Amako, K., Chuma, J., Santin, G., Broglia, L., Sei, S., Nartallo, R., Apostolakis, J., Urban, L., Barrand, G., Magni, S., Dell'Acqua, A., Wenaus, T., Stöcker, Horst, Wright, D., Morita, Y., Lockman, W., Gumplinger, P., Bellagamba, L., Savvas, N., Mora de Freitas, P., Di Salvo, E., Oohata, Y., Perl, J., Cooperman, G., Hamatsu, R., Gibin, D., Kent, P., Feliciello, A., Murakami, K., Grossheim, A., Walkden, A., Forti, A., Johnson, A., Kimura, A., Lampén, T., Sasaki, T.   +135 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Nuclear physics and nuclear astrophysics with radioactive nuclear beams [PDF]

, 1995
The various methods to produce radioactive nuclear beams, i.e. the fragmentation and ISOL methods, are reviewed and compared. The applications of these beams to nuclear astrophysics are investigated in some details, both at low and high energies ...
5. La Rabida international Summer school on nuclear physics: Response of the nuclear system to external forces, Vervier, Jean   +1 more
core  

Nuclear-physics applications of MYRRHA

EPJ Web of Conferences, 2014
The Belgian Nuclear Research Centre SCK·CEN is currently working on the design of the MYRRHA research reactor, able to operate in both critical and sub-critical mode as an Accelerator-Driven System (ADS).
Popescu Lucia
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Storage Rings For Nuclear Physics [PDF]

Annual Review of Nuclear and Particle Science, 1991
Abstract Although still a relatively new development, exploitation of the technology of storage rings has been playing an increasing role in the field of nuclear science. These few remarks present a subjective view of some of the progress and problems in this ring application.
openaire   +1 more source