Results 71 to 80 of about 947,334 (296)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Density Matrix Renormalization Group in Nuclear Physics: A Status Report

, 2003
We report on the current status of recent efforts to develop the Density Matrix Renormalization Group method for use in large-scale nuclear shell-model calculations.Comment: 6 pages, 8 figures, $^*$ Talk presented at the XXVI$^{th}$ Symposium on ...
Dimitrova, S., Dukelsky, J., Pittel, S., Stoitsov, M.   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Quantum mechanics principle and other physics principles involved in light and laser therapy

Journal of Cosmetic Medicine
Laser and light therapies have revolutionized the field of cosmetic medicine because of their ability to treat a range of dermatological conditions safely and effectively.
Cheuk Hung Lee, Kar Wai Alvin Lee, Kwin Wah Chan   +2 more
doaj   +1 more source

Chiral nucleon-nucleon forces in nuclear structure calculations [PDF]

, 2016
Realistic nuclear potentials, derived within chiral perturbation theory, are a major breakthrough in modern nuclear structure theory, since they provide a direct link between nuclear physics and its underlying theory, namely the QCD. As a matter of fact,
Coraggio, L., Gargano, A., Holt, J. W., Itaco, N., Machleidt, R., Marcucci, L. E., Sammarruca, F.   +6 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Fundamental physics studies in time domain and multi-messenger astronomy

Frontiers in Astronomy and Space Sciences
The era of ime domain and multi-messenger astronomy is not only leading to the development of a much broader set of detectors and instruments for astrophysical observations, but is also providing the means for astronomy to tie directly to cutting-edge ...
Chris Fryer
doaj   +1 more source

Strangeness nuclear physics - 2010

, 2010
Selected topics in Strangeness Nuclear Physics are reviewed: Lambda hypernuclear spectroscopy and structure, multistrangeness, and Kbar mesons in nucleiComment: Proceedings version of an Overview talk at New Frontiers in QCD 2010 (NFQCD10) - Exotic ...
Agnello, Ahn, Ahn, Ajimura, Aoki, Avraham Gal, Bart, Batty, Beane, Bielich, Dalitz, Danysz, Doté, Dover, Dover, Filikhin, Filikhin, Finelli, Friedman, Friedman, Fujiwara, Fukuda, Gazda, Gazda, Gazda, Glendenning, Haidenbauer, Harada, Hashimoto, Hayano, Hiyama, Hiyama, Hiyama, Hotchi, Hyodo, Ikeda, Iodice, Kaiser, Kishimoto, Kohno, Kohno, Magas, Mareš, Mareš, Millener, Millener, Motoba, Nagae, Nagae, Nakazawa, Nemura, Nemura, Noumi, Polinder, Ramos, Randeniya, Rijken, Schaffner, Schaffner, Shevchenko, T.Kishimoto, Takahashi, Tamura, Tanida, Wycech, Yamagata, Yamazaki   +66 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Nuclear-physics applications of MYRRHA

EPJ Web of Conferences, 2014
The Belgian Nuclear Research Centre SCK·CEN is currently working on the design of the MYRRHA research reactor, able to operate in both critical and sub-critical mode as an Accelerator-Driven System (ADS).
Popescu Lucia
doaj   +1 more source