Results 91 to 100 of about 947,334 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Shell Structure of Exotic Nuclei

, 2006
Theoretical predictions and experimental discoveries for neutron-rich, short-lived nuclei far from stability indicate that the familiar concept of nucleonic shell structure should be considered as less robust than previously thought. The notion of single-
Ando, Balian, Beiner, Bender, Bender, Berggren, Berggren, Bohr, Brown, Brown, Casten, Caurier, Chabanat, Dobaczewski, Dobaczewski, Dobaczewski, Dudek, Ehrman, Engel, Geesaman, Göppert-Mayer, Haxel, Id Betan, Ikeda, J. Dobaczewski, J. Rotureau, Janssens, Kohn, Lind, Luo, M. Płoszajczak, Magierski, Magierski, Michel, Michel, Michel, Michel, N. Michel, Okołowicz, Okołowicz, Otsuka, Otsuka, Otsuka, Perlińska, Ploszajczak, Pritychenko, Reinhard, Reinhard, Riisager, Rotureau, Sarazin, Scheerbaum, Schiffer, Sprung, Stancu, Stoitsov, Surman, Terasawa, Thomas, Vautherin, W. Nazarewicz, Wiringa, Wong, Ćwiok   +63 more
core   +3 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Electro and gamma nuclear physics in Geant4

, 2003
Adequate description of electro and gamma nuclear physics is of utmost importance in studies of electron beam-dumps and intense electron beam accelerators. I also is mandatory to describe neutron backgrounds and activation in linear colliders.
Degtyarenko, P., Kossov, M., Wellisch, J. P.   +2 more
core   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

An updated nuclear-physics and multi-messenger astrophysics framework for binary neutron star mergers. [PDF]

Nat Commun, 2023
Pang PTH, Dietrich T, Coughlin MW, Bulla M, Tews I, Almualla M, Barna T, Kiendrebeogo RW, Kunert N, Mansingh G, Reed B, Sravan N, Toivonen A, Antier S, VandenBerg RO, Heinzel J, Nedora V, Salehi P, Sharma R, Somasundaram R, Van Den Broeck C.   +20 more
europepmc   +1 more source

Understanding Supernova Neutrino Physics using Low-Energy Beta-Beams

, 2005
We show that fitting linear combinations of low-energy beta-beam spectra to supernova-neutrino energy-distributions reconstructs the response of a nuclear target to a supernova flux in a very accurate way. This allows one to make direct predictions about
Jachowicz, N., McLaughlin, G. C.
core   +1 more source