Results 81 to 90 of about 315,285 (314)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Observation of nuclear modifications in W± boson production in pPb collisions at sNN=8.16TeV [PDF]

, 2020
The production of W± bosons is studied in proton-lead (pPb) collisions at a nucleon-nucleon centre-of-mass energy of sNN=8.16TeV. Measurements are performed in the W±›µ±?µ channel using a data sample corresponding to an integrated luminosity of 173.4±6 ...
Physics Collaboration, The CMS Collaboration   +1 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

NUCLEAR PHYSICS WITH ELECTROWEAK PROBES [PDF]

Theoretical Nuclear Physics in Italy, 2005
The last few years activity of the Italian community concerning nuclear physics with electroweak probes is reviewed.Inclusive quasi-elastic electron-scattering, photon end electron induced one- and two-nucleon emission are considered. The scattering of neutrinos off nuclei in the quasi-elastic region is also discussed.
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fundamentals of Nuclear Reactor Physics [PDF]

, 2008
This new streamlined text offers a one-semester treatment of the essentials of how the fission nuclear reactor works, the various approaches to the design of reactors, and their safe and efficient operation. The book includes numerous worked-out examples
Lewis, E E
core  

Nuclear physics experiments with ion storage rings [PDF]

, 2013
In the last two decades a number of nuclear structure and astrophysics experiments were performed at heavy-ion storage rings employing unique experimental conditions offered by such machines.
Simon, H, Heinz, Andreas Martin,, Bosch, F.J.,, Bishop, S.M.,, Sun, B. H., Sun, B.H.,, Kozhuharov, C, Heinz, A, Walker, P. M., Heinz, Andreas Martin, Zhang, Y., Dillmann, I.,, Tu, X.L., Wälker, P.M., Walker, PM, Grisenti, R.E.,, Kozhuharov, C.,, Ma, X. W., Chen, LX, Wälker, P.M.,, Woods, P.J.,, Woods, P.J., Knöbel, R.K., Yamaguchi, Y, Bosch, F, Steck, M.,, Stöhlker, T., Kalantar-Nayestanaki, N., Winckler, N., Ma, X., Lestinsky, M, Nolden, F.,, Simon, H., Yamaguchi, T, Schneider, D., Bishop, S.M., Schneider, D.H.G., St\uf6hlker, T.H., Stöhlker, T.H.,, Chen, L., Chen, L.X.,, Reifarth, R., Ozawa, A, Simon, H.,, Litvinov, Yu.A.,, Heinz, A., W\ue4lker, P.M., Wakasugi, M, Leštinský, M.,, Reifarth, R.,, Steck, M, Woods, P. J., Bosch, Fritz, Geissel, H, Heil, M, Brandau, C, Schneider, D, Yamaguchi, Y.,, Brandau, C., Tu, X. L., Sun, B.H., Chen, L. X., Xu, H.,, Bishop, S., Zhang, Y.H., Ozawa, A.,, Tu, XL, Bosch, F., Bishop, S, Xu, H., Reed, M.W., Winckler, N, Sanjari, M., Woods, P., Chen, L.X., Geissel, H., Weick, H.,, Uesaka, T., Hagmann, S.,, Brandau, C.,, Yamaguchi, T., Grisenti, R., Woods, PJ, Reifarth, R, Blaum, K.,, Knoebel, R., Zhang, YH, Dillmann, I, Grisenti, RE, Walker, P., Nilsson, Thomas,, Knöbel, R.K.,, Dillmann, I., Reed, M.W.,, Geissel, H.,, Yamaguchi, T.,, Stöhlker, T.H., Stöhlker, T, Litvinov, YA, Sun, BH, Litvinov, Yu A., Zhang, Y.,, Litvinov, Yu. A., Kn\uf6bel, R.K., Nolden, F, Steck, M., Ma, X.W.,, Raabe, R.R.,, Heil, M.,, Raabe, R., Uesaka, T, Schneider, D.H.G.,, Hagmann, S, Sun, B., Raabe, Riccardo, Sanjari, M. S., Ozawa, A., Heil, M., Raabe, R.R., Knöbel, R., Bosch, F.J., Xu, H. S., Sanjari, M.S.,, Egelhof, P.,, Kalantar-Nayestanaki, N.,, Nilsson, T., Stoehlker, T., Xu, HS, Reed, MW, Litvinov, Y., Tu, X., Sanjari, MS, Weick, H, Blaum, K, Winckler, N.,, Ma, X.W., Yamaguchi, Y., Reed, M., Lestinsky, M., Leštinsk\ufd, M., Tu, X.L.,, Sanjari, M.S., Knöbel, R, Hagmann, S., Kozhuharov, C., Weick, H., Nilsson, T, Egelhof, P., Blaum, K., Wakasugi, M., Wakasugi, M.,, Grisenti, R.E., Nolden, F., Xu, H.S., Nilsson, Thomas, Egelhof, P, Zhang, Y. H., Grisenti, R. E., Kalantar-Nayestanaki, N, Ma, XW, Litvinov, Yu.A., Reed, M. W., Raabe, R, Uesaka, T.,   +163 more
core   +1 more source

Short range correlations and the isospin dependence of nuclear correlation functions [PDF]

, 2020
Pair densities and associated correlation functions provide a critical tool for introducing many-body correlations into a wide-range of effective theories.
Weiss, R, Weinstein, L.B., Hen, Or, Piasetzky, E, Schmidt, Axel, Miller, G.A., Barnea, N, Cruz Torres, Reynier   +7 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source