Results 81 to 90 of about 947,334 (296)

Nuclear Security Applications of Antineutrino Detectors: Current Capabilities and Future Prospects

, 2009
Antineutrinos are electrically neutral, nearly massless fundamental particles produced in large numbers in the cores of nuclear reactors and in nuclear explosions.
Baldwin, G., Bernstein, A., Boyer, B., Goodman, M., Learned, J., Lund, J., Reyna, D., Svoboda, R.   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Search for Cold Dark Matter and Solar Neutrinos with GENIUS and GENIUS-TF

, 2002
The new project GENIUS will cover a wide range of the parameter space of predictions of SUSY for neutralinos as cold dark matter. Further it has the potential to be a real-time detector for low-energy (pp and 7Be) solar neutrinos.
H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, H. V. Klapdor-Kleingrothaus, Heidelberg-Moscow Collab., I. V. Krivosheina, J. Ellis, J. Hellmig, J. N. Bahcall, J. N. Bahcall, L. Baudis, L. Baudis   +20 more
core   +2 more sources

Storage Rings For Nuclear Physics [PDF]

Annual Review of Nuclear and Particle Science, 1991
Abstract Although still a relatively new development, exploitation of the technology of storage rings has been playing an increasing role in the field of nuclear science. These few remarks present a subjective view of some of the progress and problems in this ring application.
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The GSI oscillation mystery

, 2010
In this talk, a short discussion of the GSI anomaly is given. We discuss the physics involved using a comparison with pion decay, and explain why the observed oscillations cannot be caused by standard neutrino mixing.Comment: 3 pages, 1 figure; part of ...
Merle, Alexander
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Nuclear Physics with Electroweak Probes

, 2009
In recent years, the italian theoretical Nuclear Physics community has played a leading role in the development of a unified approach, allowing for a consistent and fully quantitative description of the nuclear response to electromagnetic and weak probes.
Aguilar Arevalo A A (MiniBooNE), Alvioli, Barbaro M B, Benhar O, Benhar O, Benhar O, Benhar O, Czyz W, Day D, Egiyan K S, Fomin N, Garino G, Giusti C, Lipari P, Martini M, Omar Benhar, Onderwater C J C, Onderwater C J G, Sick I, Zeller G P   +19 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source