Results 71 to 80 of about 737,457 (360)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

AI-Assisted Forecasting of a Mitigated Multiple Steam Generator Tube Rupture Scenario in a Typical Nuclear Power Plant

open access: yesEnergies
This study is focused on developing a machine learning (ML) meta-model to predict the progression of a multiple steam generator tube rupture (MSGTR) accident in the APR1400 reactor.
Sonia Spisak, Aya Diab
doaj   +1 more source

Optimization and Exergy Analysis of Nuclear Heat Storage and Recovery

open access: yesEnergies, 2019
The APR1400 Nuclear Heat Storage and Recovery (NHS&R) System described here represents the conceptual design and interface of a tertiary cycle with the secondary system of the Korean nuclear reactor plant APR1400.
Anna Kluba, Robert Field
doaj   +1 more source

SEISMIC ISOLATION OF NUCLEAR POWER PLANTS

open access: yesNuclear Engineering and Technology, 2014
Seismic isolation is a viable strategy for protecting safety-related nuclear structures from the effects of moderate to severe earthquake shaking. Although seismic isolation has been deployed in nuclear structures in France and South Africa, it has not seen widespread use because of limited new build nuclear construction in the past 30 years and a lack
ANDREW S. WHITTAKER   +2 more
openaire   +3 more sources

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

open access: yesFEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo   +2 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

MILITARY NUCLEAR POWER PLANTS [PDF]

open access: yes, 1964
Abstract : This report was designed primarily to assist both Air Force planning groups and civil engineering functions in the proper adaptation of nuclear power to satisfy their requirements. Air Force, Army, and AEC interrelationships within the nuclear power program are discussed along with development and procurement procedures.
openaire   +3 more sources

Critical flow computer modelling using trace code [PDF]

open access: yes, 2022
In this paper critical flow and void fraction will be observed as a result of simulation comparing several initial data. Concerns about safety in nuclear energy industries has become number one priority after several nuclear accidents over the years ...
de Carvalho Braz, Nathan
core  

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

open access: yesFEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla   +4 more
wiley   +1 more source

The Optimal Integration of Virtual Power Plants for the South African National Grid Based on an Energy Mix as per the Integrated Resource Plan 2019: A Review

open access: yesEnergies
The Integrated Resource Plan (IRP) 2019 outlines South Africa’s goal of achieving a diverse and sustainable energy mix. To achieve this, innovative methods must be found to integrate renewable energy sources while preserving grid stability. Virtual Power
Melissa-Jade Williams, Choong-Koo Chang
doaj   +1 more source

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