Results 121 to 130 of about 3,625,064 (370)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Iran’s nuclear program - and the costs of stopping it [PDF]

This paper considers the positions of US and Israeli leaders, the current negotiations, and the possible drivers for a military strike against Iran. Over the last six months, the prospects of an Israeli preemptive strike against the Iranian nuclear ...
Rod Lyon
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Histone Deacetylase 4 Promotes Osteosarcoma Cell Proliferation and Invasion by Regulating Expression of Proliferating Cell Nuclear Antigen [PDF]

, 2019
Kun Cao, Hao Wang, Yueyang Fang, Yuan Wang, Lei Wei, Xi Chen, Zheng Jiang, Xiaochun Wei, Yong Hu   +8 more
openalex   +1 more source

Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation

, 2022
James M. Murphy, Kyuho Jeong, E. Ahn, Ssang‐Taek Lim   +3 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

India Pakistan relation and proliferation of nuclear weapons in South Asia [PDF]

, 2023
Jitendra Kumar Yadav
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

The American approach to the solution of Iranian nuclear potential problem

Studia Humanitatis, 2013
The possible vectors of cooperation with Iran concerning its nuclear weapons accumulation is analyzed in this article. The author considers the main scenarios of the international relations under conditions of sanctions and other coercive measures ...
Pavliuk Olesia Igorivna
doaj  

Assessing the nuclear weapons proliferation risks in nuclear energy newcomer countries: The case of small modular reactors

Nuclear Engineering and Technology
While several nuclear energy newcomer (NEN) countries have shown interest in small modular reactors (SMRs) as a potential energy source, this interest can generate new uncertainties regarding future nuclear weapons proliferation risks.
Philseo Kim, Sunil S. Chirayath
doaj   +1 more source