Results 51 to 60 of about 3,176,482 (331)
Is Regime Change a Solution For the Iranian Nuclear Crisis? [PDF]
Central European Journal of International & Security Studies, 2014 Since 2002, the Iranian nuclear crisis had drawn the attention of the international community and – despite renewed negotiations in the 5+1 formula – remains one of the most salient threats to international security.
Nicoleta Laşan
doaj
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
US nuclear non-proliferation policy and Ukraine
Американська історія і політика, 2017 The article deals with some aspects of US policy in the sphere of non-proliferation of nuclear weapons and Washington’s influence on the processes denuclearization Ukraine in 1992-1996.
Oleksandr Potiekhin
doaj +1 more source
Urania, 2020 PROLIFERATION RESISTANCE ASSESSMENT OF INDONESIAN 10-MWT RDE EXPERIMENTAL POWER REACTOR USING INPRO METHODOLOGY. Assessment of proliferation resistance (PR) for 10-MWt RDE has been conducted to verify the RDE safeguards desain.
Bening Farawan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mitigating the Threat of Nuclear-Weapon Proliferation via Nuclear-Submarine Programs
Journal for Peace and Nuclear Disarmament, 2019 Brazil is building a nuclear-powered attack submarine, South Korea has in the past asserted its need for nuclear-powered attack submarines to deal with the threat of North Korean nuclear-armed submarine-launched ballistic missiles, and Iran has asserted ...
Frank von Hippel
doaj +1 more source
ERK5 and Cell Proliferation: Nuclear Localization Is What Matters
Front. Cell Dev. Biol., 2016 ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell ...
N. Gómez, T. Erazo, J. Lizcano
semanticscholar +1 more source