Results 61 to 70 of about 3,176,482 (331)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The nuclear network: multiplex network analysis for interconnected systems
Applied Network Science, 2019 States facing the decision to develop a nuclear weapons program do so within a broader context of their relationships with other countries. How these diplomatic, economic, and strategic relationships impact proliferation decisions, however, remains under-
Bethany L. Goldblum +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP
OncoTarget, 2016 Renal cell carcinoma (RCC) is one of the common tumors in the urinary system without effective therapies. Angiomotin (Amot) can interact with Yes-associated protein (YAP) to either stimulate or inhibit YAP activity, playing a potential role in cell ...
Meng Lv +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Margalla Papers, 2023 The image the United States has always projected of itself in the international community is that of a state that is nuclear responsible and bears the responsibility to keep nuclear proliferation in check.
Asma Rashid , Aiman Saif Ullah
doaj
Why Do States Seek to Acquire Nuclear Weapons?
Jurnal Pertahanan: Media Informasi tentang Kajian dan Strategi Pertahanan yang Mengedepankan Identity, Nasionalism & Integrity, 2017 Conventional wisdom maintains that security concerns are the primary motivation for states to seek nuclear weapons. Indeed, history has shown that the predominant decisions to go nuclear (starting from the U.S., the Soviet Union, China, Israel, Pakistan,
Hamdan Hamedan
doaj +1 more source
Nuclear Proliferation: The Risks of Prediction [PDF]
SSRN Electronic Journal, 2018 Abstract This chapter reviews existing theoretical tools for predicting proliferation or nonproliferation, spanning a range of agents across levels of analysis. It then distills relevant considerations for exploring future scenarios in East Asia.
openaire +3 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Nuclear transport: Proliferating pathways [PDF]
Current Biology, 1997 A new pathway of nuclear import has been discovered with the identification of receptors that mediate the nuclear import of shuttling hnRNP proteins in yeast and human cells.
openaire +2 more sources