Results 61 to 70 of about 3,625,064 (370)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Nuclear Security Science and Policy Institute at Texas A&M University

International Journal of Nuclear Security, 2015
The Nuclear Security Science and Policy Institute (NSSPI) is a multidisciplinary organization at Texas A&M University and was the first U.S. academic institution focused on technical graduate education, research, and service related to the safeguarding ...
Claudio A. Gariazzo, Kelley H. Ragusa, David R. Boyle, William S. Charlton, Sunil S. Chirayath, Craig M. Marianno, Paul Nelson Jr   +6 more
doaj   +1 more source

A National Pragmatic Safety Limit for Nuclear Weapon Quantities

Safety, 2018
This study determines the nuclear pragmatic limit where the direct physical negative consequences of nuclear weapons use are counter to national interests, by assuming all unknowns are conservatively optimistic.
Joshua M. Pearce, David C. Denkenberger   +1 more
doaj   +1 more source

Supplemental Fig. 4 from Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver [PDF]

, 2023
Takeshi Hori, Kosuke Saito, Rick Moore, Gordon P. Flake, Masahiko Negishi   +4 more
openalex   +1 more source

The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation [PDF]

, 2016
Lamin A is a component of the nuclear matrix that also controls proliferation by largely unknown mechanisms. NF-Y is a ubiquitous protein involved in cell proliferation composed of three subunits (-YA -YB -YC) all required for the DNA ...
Alonzi, Tonino, Capogrossi, Maurizio C., Carlomosti, Fabrizio, Ciana, Paolo, Cicchillitti, Lucia, Dell'Anna, Maria Lucia, Dell'Omo, Giulia, Gurtner, Aymone, Magenta, Alessandra, Mancone, Carmine, Manni, Isabella, Piaggio, Giulia, Picardo, Mauro, Regazzo, Giulia, Rizzo, Maria Giulia, Spagnuolo, Manuela, Tripodi, Marco   +16 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Nuclear Weapons in the Post-Material Age: A Study on Resistance Against Nuclear Proliferation Using Data from Sweden

Journal for Peace and Nuclear Disarmament
This study examines possible drivers of public opinion towards nuclear proliferation, which is an often-overlooked aspect in the security literature.
Anton Brännlund, Albert Weckman, Paul Lundberg   +2 more
doaj   +1 more source

Calling All Actors: A Holistic Framework for Tackling Supply-Side Proliferation

International Journal of Nuclear Security, 2015
This article proposes a new holistic framework for tackling supply-side proliferation, based on a mix of punishments, incentives, and new normative standards (PIN) that could be taken by industry. After outlining a brief history of illicit nuclear trade,
Christopher Hobbs, Elisabeth Young
doaj   +1 more source

The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation [PDF]

, 2009
Objective—The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial wall’s response to injury. The identification and characterization of the NF-kB essential modulator– binding domain (NBD) peptide, which can block the activation of
Carnuccio, R., De Stefano, D., Di Lauro, M.V., Di Meglio, P., Grassia, G., Ialenti, A., Ianaro, A., Kennedy, S., Maddaluno, M., Maffia, P., Musilli, C., Parenti, A., Parratt, C.A.   +12 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source