Results 71 to 80 of about 3,625,064 (370)

Is Regime Change a Solution For the Iranian Nuclear Crisis? [PDF]

Central European Journal of International & Security Studies, 2014
Since 2002, the Iranian nuclear crisis had drawn the attention of the international community and – despite renewed negotiations in the 5+1 formula – remains one of the most salient threats to international security.
Nicoleta Laşan
doaj  

Export Control Regulations in the United Arab Emirates - Comparative Analysis with the United Kingdom [PDF]

, 2019
Governments across the world appreciate the need for checks on the transfer or exportation of commodities, information, software, and technology considered of strategic value.
Malkawi, Bashar H.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Nuclear Imminence in Contemporary Indo‐Pakistani Conflict [PDF]

, 2009
November of 2008 saw frightening attacks on India’s foreigners. Over the course of three days, hostages had been taken, hotels and restaurants in India’s busiest city of Mumbai were burned and English, American and Canadian citizens lay among the nearly ...
Tobin, Anna K.
core  

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cyber operations as nuclear counterproliferation measures [PDF]

, 2014
Focusing on recent malware that allegedly targeted Iran’s nuclear programme, this article discusses the legality of inter-state cyber operations as measures to prevent the proliferation of nuclear weapons approaching the problem from the perspective of ...
Roscini, M., Roscini, M.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

US nuclear non-proliferation policy and Ukraine

Американська історія і політика, 2017
The article deals with some aspects of US policy in the sphere of non-proliferation of nuclear weapons and Washington’s influence on the processes denuclearization Ukraine in 1992-1996.
Oleksandr Potiekhin
doaj   +1 more source

PROLIFERATION RESISTANCE ASSESSMENT OF INDONESIAN 10-MWT RDE EXPERIMENTAL POWER REACTOR USING INPRO METHODOLOGY

Urania, 2020
PROLIFERATION RESISTANCE ASSESSMENT OF INDONESIAN 10-MWT RDE EXPERIMENTAL POWER REACTOR USING INPRO METHODOLOGY. Assessment of proliferation resistance (PR) for 10-MWt RDE has been conducted to verify the RDE safeguards desain.
Bening Farawan, Mohamad Sukron Fajrin Husein, Agus Sunarto, Arief Sasongko Adhi   +3 more
doaj   +1 more source