Results 81 to 90 of about 3,176,482 (331)
The Politics of Nuclear Non-Proliferation [PDF]
Central European Journal of International & Security Studies, 2012 Since the explosion of the first atomic weapon the international system has been saddled with perceived threats to national security based around weapons of mass destruction (WMD).
Laz Etemike
doaj
Politeja, 2016 The reform of the nuclear safeguards and verification of nuclear materials as a condition of nuclear safety in the 21 Century The condition of maintaining nuclear safety in the twentieth century is to ensure a global system of nuclear materials ...
Tomasz Młynarski
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
British and French Nuclear Forces in the Second Nuclear Age
Czech Journal of International Relations, 2009 The article outlines the main theoretical models of nuclear proliferation and the motives that are driving states to obtain nuclear weapons. It also focuses on theoretical concepts dealing with variants and alternatives of the future fate of nuclear ...
Petr Suchý, Petr Vilímek
doaj
Research & Politics, 2015 In the literature on nuclear proliferation, some argue that further proliferation decreases interstate conflict, some say that it increases interstate conflict, and others indicate a non-linear relationship between these two factors.
Akisato Suzuki
doaj +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
AbstractSupporters of nuclear power expansion resist the notion that nuclear power is connected to nuclear weapons proliferation. However, nuclear power is a necessary precondition, albeit insufficient by itself, for developing nuclear weapons. Plutonium, which is produced by all nuclear reactors in their waste stream, is a primary concern because it ...
Doug Brugge, Aaron Datesman
openaire +2 more sources