Results 101 to 110 of about 8,612,670 (377)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

Nature Communications, 2020
The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization ...
Krishna C. Mudumbi, Rafal Czapiewski, Andrew Ruba, Samuel L. Junod, Yichen Li, Wangxi Luo, Christina Ngo, Valentina Ospina, Eric C. Schirmer, Weidong Yang   +9 more
doaj   +1 more source

Plastid proteome prediction for diatoms and other algae with secondary plastids of the red lineage [PDF]

, 2014
The plastids of ecologically and economically important algae from phyla such as stramenopiles, dinoflagellates and cryptophytes were acquired via a secondary endosymbiosis and are surrounded by three or four membranes.
Allen, Allen, Altschul, Apt, Armbrust, Ast, Baldi, Bendtsen, Blum, Bowler, Brown, Bruckner, Bullmann, Cavalier-Smith, Cock, Crooks, Curtis, Domergue, Emanuelsson, Emanuelsson, Fawcett, Felsner, Gould, Gould, Grigoriev, Grouneva, Gruber, Gruber, Gruber, Gschloessl, Hall, Hempel, Hempel, Horton, Huesgen, Joshi-Deo, Kilian, Kilian, Kitao, Kitao, Kroth, Kroth, Kroth, Lepetit, Liaud, Mernberger, Moog, Nielsen, Nielsen, Patron, Patron, Petersen, Schneider, Siaut, Sommer, Sturm, Tachibana, Tanaka, Terashima, Timmis, Vugrinec, Weber, Yandell   +62 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses

Viruses, 2019
Typical viral propagation involves sequential viral entry, uncoating, replication, gene transcription and protein synthesis, and virion assembly and release. Some viral proteins must be transported into host nucleus to facilitate viral propagation, which
Guohui Li, Xinyu Qi, Zhaoyang Hu, Qi Tang   +3 more
doaj   +1 more source

Nε-Formylation of lysine is a widespread post-translational modification of nuclear proteins occurring at residues involved in regulation of chromatin function

Nucleic Acids Research, 2007
Post-translational modification of histones and other chromosomal proteins regulates chromatin conformation and gene activity. Methylation and acetylation of lysyl residues are among the most frequently described modifications in these proteins.
J. Wiśniewski, A. Zougman, M. Mann
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses

Cells, 2020
The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben, Sarah C. Atkinson, Natalie A. Borg   +2 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Comparative analyses of nuclear proteome: extending its function

Frontiers in Plant Science, 2013
Organeller proteomics is an emerging technology that is critical in determining the cellular signal transduction pathways. Nucleus, the regulatory hub of the eukaryotic cell is a dynamic system and a repository of various macromolecules that serve as ...
Kanika eNarula, Niranjan eChakraborty, Asis eDatta, Subhra eChakraborty   +3 more
doaj   +1 more source