Results 51 to 60 of about 354,049 (298)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Simulations of X-ray bursts and superbursts [PDF]

, 2015
Observations of neutron star in binary systems provide powerful constrains on the physics at the surface of neutron stars. During the accretion of matter from the companion star, periodic nuclear explosion are triggered in the outer layers of the neutron
Fehlmann, Sofie
core   +1 more source

Measurement of $^{238}\mathrm{U}(n,{n}^{{'}}{\gamma}$) cross section data and their impact on reaction models [PDF]

, 2021
International audienceA better knowledge of ($n,xn$) reaction cross sections is important for both reaction modeling and energy applications. This article focuses on inelastic scattering of neutrons off $^{238}$U for which improvements are needed to ...
Stanoiu, M., Dessagne, P., Bacquias, A., Olacel, A., Hilaire, S., Nankov, N., Dupuis, M., Kawano, T., Plompen, A., Borcea, C., Wynants, R., Boromiza, M., Negret, A., Kerveno, M., de Saint Jean, C., Rouki, C., Capote, R., Rudolf, G., Belloni, F., Nyman, M., Romain, P., Bernard, D., Leconte, P., Henning, G., Drohé, J.   +24 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Novel, Low-Cost, Position-Sensitive Neutron Detector to Support Thick-Target Inverse Kinematics Experiments for Nuclear Data Measurements

Universe, 2023
High quality nuclear data lie at the heart of accurately modelling stellar systems and terrestrial nuclear reactors. However, some key reaction cross sections have large uncertainties, which limit such models in predicting isotopic abundances and other ...
R. Smith, J. P. Stowell, D. Barker, L. F. Thompson   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Progress of time-dependent nuclear reaction theory [PDF]

, 2019
This book is a compilation of the latest theoretical methods for treating models in nuclear reactions. Initial chapters in this volume explain different aspects of time-dependent nuclear density functional theory, such as numerical calculations, density ...
Iwata, Yoritaka
core  

Introduction to nuclear reactions [PDF]

, 1990
This successful textbook, now published for the first time in paperback, has been updated to incorporate recent developments in the field of Nuclear Reactions.
Satchler, George Raymond,1926-2010(viaf)68989973, Satchler, G R   +1 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source