Results 161 to 170 of about 1,364,815 (358)

Recruitment of Nuclear Receptor Corepressor and Coactivator to the Retinoic Acid Receptor by Retinoid Ligands [PDF]

, 2000
Elliott Klein, Jenny W. Wang, Berket Khalifa, Stacey A. Gavigan, Roshantha A.S. Chandraratna   +4 more
openalex   +1 more source

Supplementary Figure 11 from A Comprehensive View of Nuclear Receptor Cancer Cistromes

, 2023
Qianzi Tang, Yiwen Chen, Clifford A. Meyer, Tim Geistlinger, Mathieu Lupien, Qian Wang, Tao Liu, Yong Zhang, Myles Brown, Xiaole Shirley Liu   +9 more
openalex   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Differential Mechanisms of Nuclear Receptor Regulation by Receptor-associated Coactivator 3 [PDF]

, 2000
Christopher Leo, Hui Li, J. Don Chen
openalex   +1 more source

Supplementary Figures from Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

, 2023
Ying Chen, Sandra Catalina Camacho, Thomas R. Silvers, Albiruni R. Abdul Razak, Nashat Y. Gabrail, John F. Gerecitano, Eva Kalir, Elena Pereira, Brad R. Evans, Susan J. Ramus, Fei Huang, Nolan Priedigkeit, Estefanía Rodríguez, Michael Donovan, Faisal Khan, Tamara Kalir, Robert Sebra, Andrew Uzilov, Rong Chen, Rileen Sinha, Richard Halpert, Jean-Noël Billaud, Sharon Shacham, Dilara McCauley, Yosef Landesman, Tami Rashal, Michael Kauffman, Mansoor Raza Mirza, Morten Mau‐Sørensen, Peter Dottino, John A. Martignetti   +30 more
openalex   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Supplementary Fig. S1 from 1,1-Bis(3′-indolyl)-1-(<i>p</i>-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

, 2023
Teruo Inamoto, Sabitha Papineni, Sudhakar Chintharlapalli, Sung‐Dae Cho, Stephen Safe, Ashish M. Kamat   +5 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Nuclear translocation of the unliganded glucocorticoid receptor is influenced by membrane fluidity, but not A2AR agonism

, 2020
Daniel E. Oseid, Liqing Song, Sierra K. Lear, Anne S. Robinson   +3 more
openalex   +1 more source