Results 141 to 150 of about 1,364,815 (358)

Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1 [PDF]

, 2003
Fernand Gobeil, Sylvie G. Bernier, Alejandro Vazquez‐Tello, Sonia Brault, Martin Beauchamp, Christiane Quiniou, Anne Marilise Marrache, Daniella Checchin, Florian Sennlaub, Xin Hou, Mony Nader, Ghassan Bkaily, Alfredo Ribeiro‐da‐Silva, Edward J. Goetzl, Sylvain Chemtob   +14 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Roles of distinct nuclear receptors in diabetic cardiomyopathy

Frontiers in Pharmacology
Diabetes mellitus induces a pathophysiological disorder known as diabetic cardiomyopathy and may eventually cause heart failure. Diabetic cardiomyopathy is manifested with systolic and diastolic contractile dysfunction along with alterations in unique ...
Yangyang Zheng, Yongji Xu, Li Ji, Wenqing San, Danning Shen, Qianyou Zhou, Guoliang Meng, Jiahai Shi, Yun Chen   +8 more
doaj   +1 more source

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

Cell Reports, 2016
Reprogramming of cellular metabolism plays a central role in fueling malignant transformation, and AMPK and the PGC-1α/ERRα axis are key regulators of this process.
Étienne Audet-Walsh, David J. Papadopoli, Simon-Pierre Gravel, Tracey Yee, Gaëlle Bridon, Maxime Caron, Guillaume Bourque, Vincent Giguère, Julie St-Pierre   +8 more
doaj   +1 more source

Minireview: Regulation of Gap Junction Dynamics by Nuclear Hormone Receptors and Their Ligands [PDF]

, 2012
Gary L. Firestone, Bhumika J. Kapadia
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Nuclear Receptors

British Journal of Pharmacology, 2004
Guide to Receptors and ChannelsSPH Alexander, A Mathie, JA PetersBritish Journal of Pharmacology (2004) 141, S97–S101.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nuclear Hormone Receptor Coregulator: Role in Hormone Action, Metabolism, Growth, and Development [PDF]

, 2004
MaryAnn Mahajan, Herbert H. Samuels
openalex   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source