Results 131 to 140 of about 1,364,815 (358)

Automated segmentation of tissue images for computerized IHC analysis [PDF]

, 2010
This paper presents two automated methods for the segmentation ofimmunohistochemical tissue images that overcome the limitations of themanual approach aswell as of the existing computerized techniques.
A. Acquaviva, Borad, Boykov, Brey, Cheng, Cheng, Cregger, Cualing, Di Cataldo, Divito, E. Ficarra, E. Macii, Ficarra, Ficarra, Fuchs, Gonzalez, Gudla, Huang, Jacob, Jain, Kim, Lacroix-Triki, Landini, Long, Lopez, Luck, Markiewicz, Masmoudi, Matula, Mukherjee, Naik, Pinidiyaarachchi, Ruifrok, Ruifrok, S. Di Cataldo, Statnikov, Taneja, Theodosiou, Twellmann, Wang, Wolff, Yang, Zehntner, Zhang   +43 more
core   +1 more source

The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator [PDF]

, 2001
Angela F. Dulhunty, Peter W. Gage, Suzanne M. Curtis, Gareth Chelvanayagam, Philip Board   +4 more
openalex   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nuclear receptors as novel regulators that modulate cancer radiosensitivity and normal tissue radiotoxicity

Molecular Cancer
Nuclear receptors (NRs) are a superfamily of transcription factors that are involved in various pathophysiological processes. The human genome contains 48 types of nuclear receptors, including steroid hormone receptors (e.g., estrogen receptor [ER] and ...
Xiaochen Meng, Xiaoqian Li, Yi Gao, Shuyu Zhang   +3 more
doaj   +1 more source

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

Journal of Lipid Research, 2013
Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low.
Thomas Gautier, Willeke de Haan, Jacques Grober, Dan Ye, Matthias J. Bahr, Thierry Claudel, Niels Nijstad, Theo J.C. Van Berkel, Louis M. Havekes, Michael P. Manns, Stefan M. Willems, Pancras C.W. Hogendoorn, Laurent Lagrost, Folkert Kuipers, Miranda Van Eck, Patrick C.N. Rensen, Uwe J.F. Tietge   +16 more
doaj   +1 more source

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein [PDF]

, 2014
Ulrich Deuschle, M. Birkel, Eva Hambruch, Martin Hornberger, Olaf Kinzel, Sanja Perović‐Ottstadt, Andreas Schulz, Ulrike K. Hahn, Michael Burnet, Claus Kremoser   +9 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Immunomodulatory effects of curcumin on receptor activator of nuclear factor-kappa B ligand in periodontitis

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
Periodontitis is a chronic inflammatory disease of the tooth-supporting structures, often causing alveolar bone loss due to increased osteoclast activity mediated by receptor activator of nuclear factor-kappa B ligand.
Fiki Muhammad Ridho
doaj   +1 more source

A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]

, 2018
Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A., Frick, Karyn M., Hanson, Alicia M., Imhoff, Andrea, Kim, Jaekyoon, Lu, Xingyun, Mackinnon, Alexander Craig, Pandey, Rajesh K., Perera, K. L. Iresha Sampathi, Sem, Daniel S., Sweeney, Noreena, Van Hart, Rochelle M., Wargolet, Adam J.   +12 more
core   +4 more sources