Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
The porosity and nuclear magnetic characteristics of artificial samples with the equal grain size
Известия Томского политехнического университета: Инжиниринг георесурсовRelevance. The nuclear magnetic resonance relaxometry is a fairly new method for well logging and laboratory investigations. It is applied for determining petrophysical properties, e.g., porosity, permeability, water- and oil-saturation.
Timofey A. Yanushenko, Nikita A. Golikov
doaj +1 more source
The structure of thyroid gland in its pathology [PDF]
Саратовский научно-медицинский журнал, 2015 Objective: to identify the microscopic features of the structure of the thyroid gland in different forms of its pathology. Materials and Methods. The study is based on the thyroid glands of 199 patients of both sexes aged 21 to 74 years. Results.
Khayrullin R.M. +2 more
doaj
Differential contribution of nuclear size scaling mechanisms between Xenopus species. [PDF]
Dev Growth Differ, 2022 Heijo H, Merten CA, Hara Y.
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Proton emission imaging of the nuclear burn in inertial confinement fusion experiments [PDF]
, 2005 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2005.Includes bibliographical references.A proton core imaging system has been developed and extensively used for measuring the nuclear burn regions of inertial ...
DeCiantis, Joseph Loreto
core
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa. [PDF]
Int J Biol Sci, 2023 Martinez G +19 more
europepmc +1 more source