Results 71 to 80 of about 545,425 (311)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
France’s Nuclear Defence Strategy towards the Prospects for European Nuclear Deterrence
PolitejaThe crisis of multilateralism and the growing strategic and military rivalry between superpowers is changing the stability and balance of forces in the world.
Tomasz Młynarski
doaj +3 more sources
The Nuclear Forces and Nuclear Strategy of the People’s Republic of China
Контуры глобальных трансформаций: политика, экономика, право, 2018 The focus of the Chinese nuclear strategy is still unclear and the actual size of nuclear arsenals of the PRC has never been published officially.
K. V. Bogdanov
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Analysis of the evolution of Xe-135 in a KWU-PWR reactor using coupled codes [PDF]
, 2021 [EN] The fission product Xe-135 has a tremendous impact on the operation of the nuclear reactor and may interfere with the plant's operational capacity.
Miró Herrero, Rafael +5 more
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Studies and Rejection of Intercrystal Crosstalk on FPGA in a High-Energy Photon-Counting System
Applied SciencesIntercrystal scatter reduces system sensitivity and spatial resolution, a phenomenon that has been extensively studied in positron emission tomography (PET) systems. However, the issue is even more significant in high-energy systems.
Jiahao Chang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Bernard Brodie and the bomb: at the birth of the bipolar world
, 2015 Bernard Brodie (1910-1978) was a leading 20th century theorist and philosopher of war. A key architect of American nuclear strategy, Brodie was one of the first civilian defense intellectuals to cross over into the military world.
Zellen, Barry
core
The Arsenal and the Ballot Box: Scoping the Incompatibility of Nuclear Weapons and Democracy
International audienceThis paper systematically explores incompatibilities between nuclear weapons and democracy. Based on a procedural definition of democracy, it argues that nuclear weapons’ relationship with democracy is defined both by inherent ...
van Buuren, Sterre
core +1 more source