Results 81 to 90 of about 545,425 (311)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2012 This paper is the fifth in a series of 8 that make up the evidence base for SDC report 'The role of nuclear power in a low carbon economy'.This document is an extensive review of the nuclear waste issue, covering radioactive waste management in both ...
AMEC NNC Limited +2 more
core
Australia and nuclear strategy [PDF]
, 2019 This thesis consists of an historical and strategic analysis of Australia's relationship with nuclear weapons, nuclear strategy, and U.S. extended nuclear deterrence.
Leah, Christine Martine
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Public perceptions and community issues
, 2012 This paper is the seventh in a series of 8 that make up the evidence base for SDC report 'The role of nuclear power in a low carbon economy'.Publisher ...
Kearnes, Matthew +3 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
UKAEA's strategy for the decommissioning of its nuclear licensed sites
, 2002 This report sets out the findings of a review by the Health and Safety Executive's Nuclear Installations Inspectorate (NIl), in consultation with the environment agencies, of the technical and some financial aspects of the decommissioning strategies for ...
Great Britain. Nuclear Installations Inspectorate (United Kingdom)
core
Stakeholder Management and Sustainability Strategies in the French Nuclear Industry [PDF]
, 2011 This paper describes how a nuclear power corporation integrates sustainability into corporate strategies and practices. The case study focuses on one of the world's largest nuclear power generators and describes the corporate capture of sustainable ...
Bonnefous, A-M. +3 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source