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Advanced Engineering Materials, EarlyView.Experiments for reinforcing the diffusion bonding plane by the oxide dispersion strengthening effect are presented. Small ceramic particles (0.5 and 50 μm, respectively) are incorporated. Furthermore, ceramic particles help to penetrate stable passivation layers, enabling atomic diffusion across bonding planes. Since a ceramic–metallic interface cannot
Thomas Gietzelt +4 more
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Advanced Engineering Materials, EarlyView.In the present study, metastable CrMnNi steels with varying chemical compositions and a concomitantly altered stacking fault energy are processed via directed energy deposition and afterwards tested via tensile tests at different temperatures. The present study shows the influence of the manufacturing process on the elemental deformation mechanisms for
Julia Richter +8 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.The influence of Hot Isostatic Pressing (HIP) temperature on the microstructure and creep performance of powder bed fusion–laser beam processed CM247LC superalloy is investigated. Grain growth and γ’ precipitate evolution are characterized following HIP at varying temperatures.
Ahmed Fardan +4 more
wiley +1 more source
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Inhibitors of nuclear transport.
Current Opinion in Cell Biology, 2019Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated by members of the Importin (IMP) superfamily of transporters of α- and β-types. The first inhibitor of nuclear transport, leptomycin B (LMB), was shown to be a specific inhibitor of the IMPβ homologue Exportin 1 (EXP1) almost 20 years ago, but it has only ...
D. Jans +2 more
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Role of karyopherin nuclear transport receptors in nuclear transport by nuclear trafficking peptide
Experimental Cell Research, 2021Nuclear trafficking peptide (NTP), a cell-penetrating peptide (CPP) composed of 10 amino acids (aa) (RIFIHFRIGC), has potent nuclear trafficking activity. Recently, we established a protein-based cell engineering system by using NTP, but it remained elusive how NTP functions as a CPP with nuclear orientation.
Yoichi Teratake +2 more
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Current Opinion in Cell Biology, 1994
A striking property of nuclear pore complexes is their ability to mediate bi-directional nucleocytoplasmic traffic of proteins and RNAs. In the past year, several new nuclear pore proteins have been identified, but their precise functions remain to be established.
E, Fabre, E C, Hurt
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A striking property of nuclear pore complexes is their ability to mediate bi-directional nucleocytoplasmic traffic of proteins and RNAs. In the past year, several new nuclear pore proteins have been identified, but their precise functions remain to be established.
E, Fabre, E C, Hurt
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Nuclear transport and nuclear pores in yeast
Antonie van Leeuwenhoek, 1992The central features of nuclear import have been conserved during evolution. In yeast the nuclear accumulation of proteins follows the same selective and active transport mechanisms known from higher eukaryotes. Yeast nuclear proteins contain nuclear localization sequences (NLS) which are presumably recognized by receptors in the cytoplasm and the ...
U. Nehrbass, E. C. Hurt
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Nuclear transport and transcription
Current Opinion in Cell Biology, 2000The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation.
Arash Komeili, Erin K. O'Shea
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In or out? Regulating nuclear transport
Current Opinion in Cell Biology, 1999The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors.
Jennifer K. Hood, Pamela A. Silver
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