Results 91 to 100 of about 48,980 (246)
, 2023 Applying the international legal framework governing the use of nuclear weapons to the facts of the war in Ukraine leads to a clear answer to the question of whether the use of nuclear weapons in Ukraine by Russia would be legal.
Hart, Christopher J.
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
BiomassIt is crucial to increase the resilience of the global food production and distribution systems against the growing concerns relating to factors that could cause global catastrophic infrastructure losses, such as nuclear war or a worldwide pandemic ...
David Nelson +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Emerging Powers and the Nuclear Non-Proliferation and Disarmament Regime. Security Policy Brief 27, September 2011 [PDF]
, 2011 In this Policy Brief, Tom Sauer looks at the ambivalent position of emerging powers vis-à-vis nuclear non-proliferation and what this eventually means for the ...
Sauer, Tom
core
, 2018 This chapter explores the idea that the nuclear balance of power matters for nuclear war outcomes. It tests this proposition by analyzing simulated nuclear exchanges between the United States and its nuclear-armed rivals: Russia, China, and North Korea ...
Matthew Kroenig
core +1 more source
Judgment and Decision MakingThis study delves into the progression of nuclear war risk perceptions during the initial 6 months of the Ukraine war. It particularly investigated the influence of Italian media coverage changes and the affective tone of war representation.
Marco Lauriola +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source