Results 71 to 80 of about 33,338 (202)

The origins of Physicians for Social Responsibility (PSR) and International Physicians for the Prevention of Nuclear War (IPPNW)

open access: yesSocial Medicine, 2012
This article reviews the beginnings and history of the physicians’ antinuclear movement. The role of Victor W. Sidel, MD, is described, particularly his involvement with Physicians for Social Responsibility (PSR) and International Physicians for the ...
Sidney Alexander
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Humanitarian and public health efforts are needed to eradicate nuclear weapons

open access: yesAustralian and New Zealand Journal of Public Health, 2012
Tilman Ruff, Ira Helfand
doaj   +1 more source

Nuclear War as It Looks

open access: yesВестник войск РХБ защиты
Currently, there are practically no people left who have seen the consequences of the use of nuclear weapons. This is the reason for certain frivolous statements about the advisability of using tactical nuclear weapons to solve certain tactical problems.
M. V. Supotnitskiy
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Development and Validation of Anxiety Due to Nuclear War Threat Scale

open access: yesPsychological Topics
Anxiety is a common reaction to the threat of nuclear war, and there is a need for a reliable and valid measure to assess it. Existing questionnaires on the specific anxiety due to the danger of nuclear war only measure some of the four clusters of ...
Vicko Ćudina   +4 more
doaj   +2 more sources

Valuing or devaluing nuclear weapons in the war journalism: a cross-national comparative content analysis of news coverage during the Russian war in Ukraine

open access: yesHumanities & Social Sciences Communications
This study adopted a comparative content analysis approach to examine the extent of media coverage of the Russian war in Ukraine by three newspapers from the United States, the United Kingdom, and China. Drawing upon the framework of war/peace journalism
Yu Guo, Xiubin Duan, Xiaodong Yang
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

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