Results 81 to 90 of about 48,980 (246)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Frank Zeidler, Milwaukee, and Cold War Civil Defense
, 2012 Civil defense in the Cold War encompassed the development of government policies and procedures to evacuate, shelter, and decentralizing American populations and industries in the event of a nuclear war.
Smith, Kenneth A. Jr
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Nuclear-armed submarines in Indo-Pacific Asia: stabiliser or menace? [PDF]
, 2015 This report examines the implications of sea-based nuclear weapons for strategic stability in the Indo-Pacific. This paper is part of a wider research and outreach project on nuclear stability in a changing Indo-Pacific Asia, supported by a grant from ...
Brendan Thomas-Noone, Rory Medcalf
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Ukraine, Nuclear Weapons, and the Future of International Law
, 2023 Russian president Vladimir Putin’s invasion of Ukraine has confronted the international community with fateful questions: whether the minimum world public order constructed after World War II is to survive, whether nuclear powers are free to commit ...
Rostow, Nicholas
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Humanities & Social Sciences CommunicationsThis study adopted a comparative content analysis approach to examine the extent of media coverage of the Russian war in Ukraine by three newspapers from the United States, the United Kingdom, and China. Drawing upon the framework of war/peace journalism
Yu Guo, Xiubin Duan, Xiaodong Yang
doaj +1 more source
Vulcan Survivability in Nuclear War
Air and Space Power Review, 2023 Post the Royal Air Force’s nuclear deterrent role, and the end of Britain’s V-bomber force, several academic papers have questioned the ability of the V-force to survive long enough over the Soviet Union to release its nuclear weapons onto its Supreme ...
Julian Grenfell
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The EU and Iran’s Nuclear Programme: Testing the Limits of Coercive Diplomacy. College of Europe EU Diplomacy Paper 1/2009 [PDF]
, 2009 The paper analyzes the E-3’s/EU’s diplomatic strategy vis-à-vis Iran and its nuclear programme against the theoretical background of coercive diplomacy.
Tocha, Monika.
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