Results 61 to 70 of about 470,414 (263)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Don’t Talk About Your Fallout Shelter: Civilian Perceptions of Threat and Structural Responses during the Cold War in Regina, Saskatchewan between 1958 and 1963 [PDF]
, 2019 During the Cold War, the Canadian government initiated a civil defence campaign urging private citizens to construct shelters to protect themselves from the effects of nuclear fallout.
Mushynsky, Julie
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Trump Administration’s Nuclear Posture Review (NPR): In Historical Perspective
Journal for Peace and Nuclear Disarmament, 2018 Except for the Eisenhower administration’s threat of nuclear retaliation to even local non-nuclear and limited aggression, the Trump administration’s Nuclear Posture Review (NPR) is the most open description of US capabilities and strategies for ...
Seyom Brown
doaj +1 more source
Clinical Sociology and Preventing Nuclear War [PDF]
, 1986 This paper outlines major kinds of social science research, especially sociological, that have relevance for nuclear war prevention and that would be relevant to a variety of clients. Research that has been done as well as work that could be done to help
Kriesberg, Louis
core +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Mediating memory: Shōjo and war memory in classical narrative Japanese cinema [PDF]
, 2017 Considering the impact of the trope of the shōjo, or girl trope in post-war Japanese cinema, this paper argues for the repeated motif as a key factor in the creation of a particular affective economy around the memorialization of war in Japan.
Coates, Jennifer
core +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Creating a Canadian profession: the nuclear engineer, c. 1940-1968 [PDF]
, 2009 Canada, as one of the three Allied nations collaborating on atomic energy development during the Second World War, had an early start in applying its new knowledge and defining a new profession. Owing to postwar secrecy and distinct national aims for the
Johnston, S.F.
core +1 more source