Results 111 to 120 of about 6,071,343 (411)

Fast and sensitive determination of camel's and goat's meat and milk using species-specific genetic markers [PDF]

Biotechnology in Animal Husbandry, 2015
For the fast and sensitive determination of camel's and goat's meat and milk, species-specific regions (SSR) of follicle stimulating hormone receptor (FSHR) gene in both camel and goat were amplified using PCR technique.
Abdel-Rahman S.M., Elmaghraby A.M., Haggag A. S.   +2 more
doaj  

HiTRACE: High-throughput robust analysis for capillary electrophoresis [PDF]

, 2011
Motivation: Capillary electrophoresis (CE) of nucleic acids is a workhorse technology underlying high-throughput genome analysis and large-scale chemical mapping for nucleic acid structural inference. Despite the wide availability of CE-based instruments,
Bylund, Cormen, Cover, Das, Das, Deigan, Ewing, Ewing, Hanjoo Kim, Jinkyu Kim, Justine Hum, Kay, Kazmi, Kladwang, Kladwang, Laederach, Levenberg, Marquardt, Merino, Mitra, Nielsen, Oppenheim, Peattie, Pravdova, Rhiju Das, Robinson, Ruiz-Martinez, Seunghyun Park, Sungroh Yoon, Tijerina, Tomasi, Vasa, Walczak, Watts, Weeks, Wilkinson, Wipapat Kladwang, Wong, Woolley, Xi   +39 more
core   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Visualizing RNA conformational and architectural heterogeneity in solution

Nature Communications, 2023
RNA conformational heterogeneity is important to diverse functions. Here, the authors use AFM to directly visualize individual RNA molecules that are in various conformational states under near physiological solution conditions for the first time.
Jienyu Ding, Yun-Tzai Lee, Yuba Bhandari, Charles D. Schwieters, Lixin Fan, Ping Yu, Sergey G. Tarosov, Jason R. Stagno, Buyong Ma, Ruth Nussinov, Alan Rein, Jinwei Zhang, Yun-Xing Wang   +12 more
doaj   +1 more source

Self-Awareness: Nucleic Acid-Driven Inflammation and the Type I Interferonopathies.

Annual Review of Immunology, 2019
Recognition of foreign nucleic acids is the primary mechanism by which a type I interferon-mediated antiviral response is triggered. Given that human cells are replete with DNA and RNA, this evolutionary strategy poses an inherent biological challenge, i.
C. Uggenti, A. Lepelley, Y. Crow
semanticscholar   +1 more source

Redesigning nucleic acids [PDF]

Pure and Applied Chemistry, 1998
Abstract
Simon E. Moroney, Christophe Hammer, Michael J. Lutz, Birgitte Hyrup, M. Blättler, Simona C. Jurczyk, Joseph Stackhouse, Andrew L. Roughton, Joseph A. Piccirilli, Christopher Switzer, Stefan Lutz, D. K. Bäschlin, U. von Krosigk, Steven A. Benner, Krishnan P. Nambiar, Heike A. Held, H. A. König, Clemens Richert, Thomas F. Jenny, Tuncer Arslan, J. T. Kodra, Jurgen G. Schmidt, Zh. Huang, Martin Egli, Klaus Schneider, E. Müller, L. J. MacPherson, Thomas R. Battersby, Bernd Eschgfäller, Daniel Hutter, J. J. Vögel, Jennifer Horlacher   +31 more
openaire   +3 more sources

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Flexibility of nucleic acids: from DNA to RNA [PDF]

arXiv, 2015
The structural flexibility of nucleic acids plays a key role in many fundamental life processes, such as gene replication and expression, DNA-protein recognition, and gene regulation. To obtain a thorough understanding of nucleic acid flexibility, extensive studies have been performed using various experimental methods and theoretical models.
arxiv  

Self-partitioning SlipChip for slip-induced droplet formation and human papillomavirus viral load quantification with digital LAMP [PDF]

, 2020
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide, and persistent HPV infection can cause warts and even cancer.
Han, Xu, Ismagilov, Rustem F., Lai, Dongmei, Lyu, Weiyuan, Qu, Haijun, Shen, Feng, Wang, Qian, Yu, Mengchao, Yu, Ziqing   +8 more
core  

Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics

Nucleic Acids Research, 2019
Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence homology with ...
Jinzhao Song, Jorrit W. Hegge, M. Mauk, Junman Chen, Jacob E. Till, Neha Bhagwat, Lotte T. Azink, Jing Peng, Moen Sen, Jazmine Mays, E. Carpenter, John van der Oost, H. Bau   +12 more
semanticscholar   +1 more source