Results 81 to 90 of about 781,538 (317)
Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery
Advanced Functional Materials, EarlyView.This study optimizes two methods for the generation of extracellular vesicle (EV)‐mimetic‐Lipid Nanoparticle (LNP) (CELLNPs) and EV‐LNP (HEVs) hybrid nanoparticles for messenger (mRNA) delivery. The authors screen lipid compositions to maximize hybrid nanoparticle formation and analyze the resulting nanoparticles with single particle characterization ...
Ana Filipa Louro +6 more
wiley +1 more source
Chemosensors, 2015 Detection of low-abundance nucleic acids is a challenging task, which over the last two decades has been solved using enzymatic target amplification.
Laura Miotke +2 more
doaj +1 more source
Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics [PDF]
, 2016 Yuanyu Huang
openalex +1 more source
, 2017 Organisms throughout biology need to maintain the integrity of their genome. From bacteria to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign genetic material or to restrict its function and replication. Tremendous progress has been made in the understanding of these mechanisms which keep foreign or unwanted ...
openaire +2 more sources
Advanced Functional Materials, EarlyView.The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong +7 more
wiley +1 more source
eLife, 2013 Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with ...
Benjamin JM Taylor +8 more
doaj +1 more source
Smart Nanogels as Enzyme‐Driven Nanomotors for Navigating Viscous Physiological Barriers
Advanced Functional Materials, EarlyView.Two families of urease‐powered nanomotors (NMs), with and without a p‐(2‐hydroxyethyl methacrylate) (p‐HEMA) shell, have been successfully prepared. Both types exhibit effective motion in highly viscous synovial fluid media at low urea concentrations (25 mM).
David Esporrín‐Ubieto +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti +3 more
wiley +1 more source
Journal of NanobiotechnologyRecent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy.
Yamei Chen +6 more
doaj +1 more source
Recent Applications of Albumin as a Green and Versatile Catalyst in Organic Synthesis
MoleculesToday, biocatalytic methodologies are well established as useful tools in green organic synthesis, since biocatalysts are mild, sustainable, and environmentally friendly catalysts which provide selectivity to the reactions they catalyse.
Estefanía L. Borucki, Luis E. Iglesias
doaj +1 more source