Results 141 to 150 of about 210,426 (263)

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Clinical utility of nucleic acid amplification testing for detection of sexually transmitted infections in women with symptomatic bacterial vaginosis and vulvovaginal candidiasis identified by conventional versus molecular diagnoses. [PDF]

J Clin Microbiol
Getman D, Seña AC, Nenninger A, Schwebke JR.   +3 more
europepmc   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Impact of rapid nucleic acid amplification tests for tuberculosis on patient outcomes. [PDF]

Cochrane Database Syst Rev
Otieno JA, Were LM, Lutje V, Scandrett K, Takwoingi Y, Ochodo EA.   +5 more
europepmc   +1 more source

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

Point-of-Care Nucleic Acid Amplification Tests for Respiratory Syncytial Virus Detection in Children and Adults: A Systematic Literature Review. [PDF]

Infect Dis Ther
Date K, Fowler K, Baniecki ML, Perez KK, Toussi SS, Thomas E, Schneider KT, Ruiz O, Seabroke S, Chatzikonstantinidou K, Sarabia LE, Gessner B, Begier E.   +12 more
europepmc   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Relationship Between <i>Clostridioides difficile</i> Stool Concentration, Nucleic Acid Amplification Test Results, and Environmental Contamination. [PDF]

Open Forum Infect Dis
Lee MM, Reske KA, Hink T, Fishbein SRS, Newcomer EP, Cass C, Olsen MA, Dantas G, Burnham CD, Dubberke ER.   +9 more
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Incremental diagnostic yield of consecutive sputum nucleic acid amplification tests for pulmonary tuberculosis. [PDF]

Microbiol Spectr
Kanokogi T, Urabe N, Tokita N, Murakami H, Sasaki M, Sakamoto S, Kishi K.   +6 more
europepmc   +1 more source