Results 151 to 160 of about 186,936 (344)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Diagnostic accuracy of Truenat in extrapulmonary tuberculosis

Journal of Family Medicine and Primary Care
Background: Diagnosing extrapulmonary tuberculosis (EPTB) remains a challenge even in today’s era. Truenat, an indigenously developed nucleic acid amplification test (NAAT), has reported high sensitivity and specificity in sputum samples.
Abhisek Das, Saswat Subhankar, C. Mohan Rao, Amrut Kumar Mohapatra, Sunil Swick Rout, Surya Teja Meka, Yashaswi R. Bharadwaj Akkiraju   +6 more
doaj   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Photoelectrochemical Detection of Dengue-Related Oligonucleotide Sequence Using Anthocyanin as an Intercalating Agent and Electrochromic Material [PDF]

, 2010
World Health Organization (WHO) presupposes a confirmation of dengue virus infection diagnosis with two criteria, i.e. clinical and laboratory criteria.
Ibrahim, A. S. (Anwar), Kusmardi, K. (Kusmardi), Tedjo, A. (Aryo)   +2 more
core  

The Core–Shell Conformational Space of Compartmentalized Single‐Chain Nanoparticles by Paramagnetic and Hyperpolarized NMR Spectroscopy

Advanced Science, EarlyView.
Combinations of integrative NMR spectroscopy and molecular dynamics simulations reveal the internal structural dynamics of single‐chain nanoparticles. Abstract Single‐chain nanoparticles (SCNPs) are formed by the collapse of individual polymer chains, generating entities comparable to proteins in size, internal structure, and function.
Federico Faglia, Justus F. Thümmler, Christopher Pötzl, Milan Zachrdla, Ertan Turhan, Dennis Kurzbach, Wolfgang H. Binder   +6 more
wiley   +1 more source

Raman Spectroscopy: A Promising Technique for Analyzing Nucleic Acid Refractory to PCR Amplification [PDF]

, 2014
Milad Soleimani, Rachel Matar, Maxime Merheb   +2 more
openalex   +1 more source

Nucleic acid probes in diagnostic medicine [PDF]

The need for improved diagnostic procedures is outlined and variations in probe technology are briefly reviewed. A discussion of the application of probe technology to the diagnosis of disease in animals and humans is presented.
Oberry, Phillip A.
core   +1 more source

A Microfluidic Digital Shutter of Liquid–Liquid Interface for Fabrication of Multifaceted Hydrogel Microfiber Structure

Advanced Science, EarlyView.
A programmable passive digital shutter based on multiphase liquid–liquid interface dynamics is introduced for precise fabrication of hydrogel microfibers. By modulating the shutter operation, microfibers with tunable geometry—including linear, helical, tadpole‐like, and spherical forms—are produced.
Dongrui Zhang, Jiangyue Liu, Hao Ye, Yu Shen, Haoran Su, Zhuqing Liang, Kexin Li, Xing Zhang, Shiyi Yang, Yunfei Lu, Zhexi Zhang, Sihang Liu, Yi Huang, Xiao Liu, Yubo Fan   +14 more
wiley   +1 more source

Microfluidic Encapsulation of DNAs in Liquid Beads for Digital Loop‐Mediated Isothermal Amplification

Advanced NanoBiomed Research
Digital nucleic acid analysis has emerged as a prominent tool for the detection and absolute quantification of diverse pathogens. Digital loop‐mediated isothermal amplification (dLAMP) offers highly sensitive, specific, time‐efficient, and cost‐effective
Fariba Malekpour Galogahi, Simon Strachan, Ajeet Singh Yadav, Helen Stratton, Nam‐Trung Nguyen   +4 more
doaj   +1 more source