Results 121 to 130 of about 2,997,790 (301)

A Cyclopentane Conformational Restraint for a Peptide Nucleic Acid:  Design, Asymmetric Synthesis, and Improved Binding Affinity to DNA and RNA

, 2016
A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is proposed.
Toshiaki Hara (2476915), Mark A. Witschi (1903096), John M. Franck (1325163), Russell D. Haynes (2676577), Michael C. Myers (243226), Andrzej Grajkowski (9751), Nataliya V. Larionova (3067266), Daniel H. Appella (226905)   +7 more
core   +2 more sources

Nucleic acid enzymes: The fusion of self-assembly and conformational computing

, 2009
Macromolecules are the predominant physical substrate sup-porting information processing in organisms. Two key characteristics—conformational dynamics and self-assembly properties—render macro-molecules unique in this context.
Zauner, K.-P., Ramlan, E. I.
core   +1 more source

Synchrotron-radiation vacuum-ultraviolet circular dichroism spectroscopy in structural biology: an overview

Biophysics and Physicobiology, 2019
Circular dichroism spectroscopy is widely used for analyzing the structures of chiral molecules, including biomolecules. Vacuum-ultraviolet circular dichroism (VUVCD) spectroscopy using synchrotron radiation can extend the short-wavelength limit into the
Kunihiko Gekko
doaj   +1 more source

Conformational Control of Thymine Photodimerization in Single-Strand and Duplex DNA Containing Locked Nucleic Acid TT Steps

, 2016
The results of an integrated experimental and theoretical study of thymine−thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported.
Frederick D. Lewis (1278270), Martin McCullagh (1278264), George C. Schatz (1278267), Mahesh Hariharan (1269246)   +3 more
core   +1 more source

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Nucleic acid stain-dependent single strand conformation polymorphisms

BioTechniques, 2004
David R. McKee, M. Scott Thomson
doaj   +1 more source

Dephosphorylation-regulated MNAzyme-PER cascade as a programmable converter for multi-task molecular actuation

Journal of Nanobiotechnology
Nucleic acid conformational regulation and enzymatic dynamic modulation play a pivotal role in creating collaborative amplification systems with programmable responses.
Yaoyi Zhang, Yiqi Zhang, Jianbo Jiang, Dan Bai, Li Zhang, Li Wang, Xingping Hu, Jiu Pu, Yu He, Xiaole Han, Weitao Wang, Na Yin, Xiaomei Lin, Xingyu Liu, Tingmei Chen, Yongcan Guo, Guoming Xie   +16 more
doaj   +1 more source

The Progress and Evolving Trends in Nucleic-Acid-Based Therapies

Nucleic-acid-based therapies have emerged as a pivotal domain within contemporary biomedical science, marked by significant advancements in recent years. These innovative treatments primarily operate through the precise binding of DNA or RNA molecules to
Chunmiao Wang, Mengtian Ren, Xiuping Fu, Yunlong Liu   +3 more
core   +1 more source

Conformational Control of Thymine Photodimerization in Single-Strand and Duplex DNA Containing Locked Nucleic Acid TT Steps

, 2010
The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported.
Mahesh Hariharan, Frederick D. Lewis, George C. Schatz, Lewis, Frederick D., McCullagh, Martin, Martin McCullagh, Hariharan, Mahesh, Schatz, George C.   +7 more
core   +1 more source

Flexible Sensors for Robotics Tactile Perception: A Review

Advanced Robotics Research, EarlyView.
Flexible tactile sensing for robotics is reviewed through four interconnected dimensions. Physical mechanisms include piezoresistive, capacitive, piezoelectric, triboelectric, iontronic, and optical sensing. Structural design includes bioinspired, defect‐based, and MEMS‐based tactile systems.
Yu Song, Ying Chen, Yihao Chen, Xue Feng
wiley   +1 more source