Results 101 to 110 of about 2,476,402 (307)

Building biologically active nucleic acid nanocomplexes

, 2008
The Bioplex technology allows the hybridization of functional entities to various forms of nucleic acids by the use of synthetic nucleic acid analogs.
Svahn, MG, Wenska, M, Lundin, KE, Strömberg, R,, Simonson, OE, Moreno, PMD, Smith, CIE   +6 more
core   +1 more source

Re-Evaluating the Spherical-Nucleic-Acid Technology [PDF]

, 2018
We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.
Víctor F., Puntes, Joanna, Bereta, Raphaël, Lévy, David, Mason, Paolo, Bergese, Gal, Haimovich, Maria, Czarnek   +6 more
core   +1 more source

Survey of Conductive Polymers for the Fabrication of Conformation Switching Nucleic Acid-Based Electrochemical Biosensors

, 2023
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsapm.3c02206.Electrochemical biosensors are a continuously evolving technology with great potential for applications in human health. With the continuous glucose
Arroyo-Currás, Netzahualcóyotl, Wang, Bo, Herranz Astudillo, María Ángeles, Mallires, Kyle, Lión Villar, Juan, Kavner, Jonathan, Harris, Jonathan, Shaver, Alexander, Martín León, Nazario, Gottlieb, Rebecca   +9 more
core   +1 more source

Rapid In-Vitro Inactivation of Various SARS-CoV-2 Strains Using Ionizing Radiation: New Inactivation Patterns and Mechanistic Insights

Engineering
Ionizing radiation presents an important solution for virus inactivation. However, its efficacy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation and the underlying mechanisms remain unclear.
Wei Wang, Xiaodi Zhang, Jiageng Yu, Tianhao Weng, Zhiyang Yu, Zhigang Wu, Danrong Shi, Sufen Zhang, Xiangyun Lu, Osama Alam, Dahang Shen, Qian Bao, Qingfu Ye, Lanjuan Li, Hangping Yao   +14 more
doaj   +1 more source

The electrostatic field of DNA: the role of the nucleic acid conformation

Nucleic Acids Research, 1982
Calculations of the electrostatic field of DNA in two very different double helical conformations, A and Z, are reported and compared with the results previously obtained for B-DNA. Striking contrasts between these fields and the associated electrostatic potentials are brought into evidence.
Lavery, R., Pullman, B.
openaire   +4 more sources

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Plant pathogen diagnostics: immunological and nucleic acid-based approaches

, 2004
Accurate disease diagnosis and precise identification of any pathogens involved is an essential prerequisite for understanding plant diseases and controlling them effectively.
Fraaije, B. A., Foster, S. J., Ward, E., McCartney, H. A.   +3 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures

, 2015
The facile ability of DNA to self-assemble has enabled the creation of complex architectures with diverse functions on surfaces or in solution. This approach provides a powerful design tool for the development of nanoscale devices with transformative ...
Lucia Coral, Redhu, Shiv K., Nicholson, Allen W., CASTRONOVO, MATTEO, Allen W. Nicholson, Vincenzo Carnevale, STOPAR, ALEX, Matteo Castronovo, CORAL, LUCIA, Carnevale, Vincenzo, Shiv K. Redhu, Alex Stopar   +11 more
core   +1 more source

An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping

Communications Chemistry
End capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen, Chunlei Zhang, Xue Chen, Ziwen Dai, Mengting Li, Wenjian Ma, ChiYung Yam, Xiaoluo Huang, Chenghe Xiong, Hui Mei   +9 more
doaj   +1 more source