Results 81 to 90 of about 2,476,402 (307)

Blind predictions of DNA and RNA tweezers experiments with force and torque.

PLoS Computational Biology, 2014
Single-molecule tweezers measurements of double-stranded nucleic acids (dsDNA and dsRNA) provide unprecedented opportunities to dissect how these fundamental molecules respond to forces and torques analogous to those applied by topoisomerases, viral ...
Fang-Chieh Chou, Jan Lipfert, Rhiju Das
doaj   +1 more source

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, EarlyView.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source

Drug-nucleic acid interactions /

, 2001
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.Includes ...
Chaires, Jonathan B.,editor., Waring, Michael J.,editor.   +1 more
core  

Nucleic Acid (Patent US 2009/0019559 A1) [PDF]

, 2009
The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Delta8-desaturase and a Delta5-desaturase enzyme.
Sayanova, O. V., Caleron, M. V., Napier, J. A.   +2 more
core  

Single-molecule mechanostructural fingerprinting of nucleic acid conformations

Nucleic Acids Research
Abstract Understanding the three-dimensional structure and mechanical response of biomolecules is key to uncovering their molecular mechanisms, particularly in contexts where force plays a regulatory role. Structural methods such as X-ray crystallography, Cryo-electron microscopy, and Nuclear Magnetic Resonance (NMR) spectroscopy ...
Prakash Shrestha, Hans T Bergal, William M Shih, Wesley P Wong   +3 more
openaire   +4 more sources

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Nucleic Acid (Patent WO 2007/093776 A2) [PDF]

, 2007
The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a ?8-desaturase and a ?5-desaturase enzyme.
Sayanova, O. V., Napier, J. A., Venegas, C. M.   +2 more
core  

Silencing disease genes in the laboratory and the clinic

, 2011
Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Jonathan K Watts, David R Corey, Corey, David R., Watts, Jonathan K.   +3 more
core   +1 more source

Functional nucleic acids as substrate for information processing

, 2009
Information processing applications driven by self-assembly and conformation dynamics of nucleic acids are possible. These underlying paradigms (self-assembly and conformation dynamics) are essential for natural information processors as illustrated by ...
Ramlan, Effirul I.
core   +1 more source

MD SIMULATION STUDIES TO INVESTIGATE ISO-ENERGETIC CONFORMATIONAL BEHAVIOUR OF MODIFIED NUCLEOSIDES M2G AND M22G PRESENT IN tRNA

Computational and Structural Biotechnology Journal, 2013
Modified nucleic acid bases are most commonly found in tRNA. These may contain modifications from simple methylation to addition of bulky groups. Methylation of the four canonical nucleotide bases at a wide variety of positions is particularly prominent ...
Rohit S Bavi, Susmit B Sambhare, Kailas D Sonawane   +2 more
doaj   +1 more source