Results 191 to 200 of about 95,624 (263)

Cryo-EM maps of human DNA polymerase ε should be reevaluated in light of its unexpected behavior in vitro. [PDF]

Proc Natl Acad Sci U S A
Roske JJ, Yeeles JTP.
europepmc   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Modulating G-quadruplexes for therapeutic intervention: Structural diversity, stability, and emerging nucleic-acid-based strategies. [PDF]

Mol Ther Nucleic Acids
Sokulska M, Nalewaj M, Czapik T, Rachwalak M, Szabat M.   +4 more
europepmc   +1 more source

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

A universal and orthogonal safety valve for CRISPR/Cas12a without chemical modification or external stimulation. [PDF]

Nucleic Acids Res
Luo W, Wu Y, Ni D, Zhang L, Zhang Y, Han X, Zhang Y, Pu J, He Y, Yin N, Wang W, Huang R, Guo Y, Sun Y, Xie G.   +14 more
europepmc   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Reshaping of the substrate-binding pocket to improve the catalytic activity of the non-specific endonuclease from <i>Pseudomonas fluorescens</i>. [PDF]

Front Bioeng Biotechnol
Zhang JY, Zhou LJ, Zhou Q, Si WJ, Wu Y, Zhang YW.   +5 more
europepmc   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

crRNA scaffold remodeling controls CRISPR-Cas12a activity for enhanced performance. [PDF]

Nucleic Acids Res
Wang Z, Wu Y, Wang Z, Zhang S, Liu H, Nie Y, Chen K, Huang Y, Zhou Y, Cao Y, Sun L, Hao R.   +11 more
europepmc   +1 more source

CONFORMATIONAL STUDIES OF NUCLEIC ACIDS

, 1984
openaire   +1 more source